286947-77-1

Usage

Uses

Used in Pharmaceutical Industry:
2,3-dichloro-α-phenylbenzenemethanol is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its role in the production of drugs is crucial, as it serves as a building block for the development of new medications.
Used in Agricultural Chemicals:
In the agricultural sector, 2,3-dichloro-α-phenylbenzenemethanol is utilized as an intermediate in the synthesis of agrochemicals. Its presence in these products helps in the development of more effective and targeted pest control solutions.
Used in Personal Care Products:
2,3-dichloro-α-phenylbenzenemethanol is used as an antimicrobial and antifungal agent in personal care products. Its inclusion in these products helps to maintain hygiene and prevent the growth of harmful microorganisms on the skin.
Used in Disinfectants:
2,3-dichloro-α-phenylbenzenemethanol is also used in the formulation of disinfectants, where its antimicrobial properties contribute to the overall effectiveness of the product in killing or inhibiting the growth of microorganisms.
Used in Anti-inflammatory and Analgesic Applications:
2,3-dichloro-α-phenylbenzenemethanol has been studied for its potential use as an anti-inflammatory and analgesic agent. Its properties in this area suggest that it could be a valuable component in the development of new treatments for pain and inflammation.

Upstream product

• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 100-52-7 benzaldehyde 
• 108-86-1 bromobenzene 

Downstream Products

• 1042414-14-1 1-benzhydryl-3-[(2,3-dichlorophenyl)-phenyl-methoxy]-azetidine 
• 1218781-15-7 C₁₃H₉Cl₃ 
• 19920-08-2 (2,3-dichlorophenyl)(phenyl)methanone 

Relevant academic research and scientific papers

Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones

A highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane was developed using chiral imidazole iminopyridine as a ligand to access chiral benzhydrols in good to excellent yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance. Chiral biologically active 3-substituted phthalide and (S)-neobenodine could be easily constructed through asymmetric hydroboration as a key step.

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase

Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) have been reported and analyzed in the clinic, fewer inhibitors have been described for tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase-2 (IDO2) which also have been implicated more recently in cancer, inflammation and immune control. Consequently the development of dual or pan inhibitors of these Trp catabolizing enzymes may represent a therapeutically important area of research. This is the first report to describe the development of dual and pan inhibitors of IDO1, TDO and IDO2.

Cobalt-Catalyzed Asymmetric Hydrogenation of 1,1-Diarylethenes

Highly enantioselective cobalt-catalyzed hydrogenation of 1,1-diarylethenes was developed by using bench-stable chiral oxazoline iminopyridine-cobalt complexes as precatalysts. A unique o-chloride effect was observed to achieve high enantioselectivity. Easy removal as well as further transformations of the chloro group make this protocol a potentially useful alternative to synthesize various chiral 1,1-diarylethanes. This process can be successfully performed under 1 atm of hydrogen at room temperature on gram scale.

Directed magnesiation of polyhaloaromatics using the tetramethylpiperidylmagnesium reagents TMP2Mg×2 LiCl and TMPMgCl×LiCl

A convenient and efficient functionalization of polyhaloaromatics via regioselective magnesiation has been developed. Starting from simple, inexpensive but structurally challenging arenes, metallation by magnesium amide bases was achieved under mild conditions. The desired Grignard reagents were stable towards aryne formation, were obtained in good yields within short reaction times and could be reacted with a variety of typical electrophiles, providing attractive, functionalized building blocks in good to excellent yields. As an application we have prepared the antimicrobial natural product 2,6-dichloro-3-phenethylphenol isolated from the New Zealand liverwort Riccardia marginata. This synthesis involves a mixed bimetallic compound prepared via metallation of a phenylboronic acid pinacol ester derivative and subsequent selective cross-coupling. Copyright

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors

A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC50 values in the range of 10-150 nM and selectivity over the L-type channels up to nearly 1200-fold. Orally administered compounds 5 and 21 exhibited both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain.

Convenient synthesis of structurally novel 1,3-disubstituted azetidine derivatives

A convenient synthesis of structurally novel 1,3-disubstituted azetidine derivatives is described. The approach involves condensation of an azetidine building block with sulfonylated carbamic acid methyl ester, subsequently followed by quenching the imidoyl chloride with amines. Different derivatives were prepared by substituting benzhydrol as well as benzenesulfonamide as part of the core structure. Copyright Taylor & Francis Group, LLC.