286961-94-2Relevant academic research and scientific papers
Synthesis and Synthetic Application of α-Formylvinylphosphonates. Facile Synthesis of Phosphono-Substituted Heterocyclic Compounds
Kouno, Ryoji,Tsubota, Terunobu,Okauchi, Tatsuo,Minami, Toru
, p. 4326 - 4332 (2000)
The β-ethoxy-α-phosphonovinyl anion, generated from β-(ethoxy)vinylphosphonate 1 and LDA, reacted with aldehydes and ketones or phenyl isocyanate to give the corresponding allylic alcohols 2a - m or 1,3-diphenyl-5-phosphonouracil 4 in good or moderate yields. Treatment of the alcohols 2a - d,g,h,j with trifluoroacetic acid led to α-formylvinylphosphonates 5a - d,g,h,j in excellent yields. Synthetic application of the α-formylvinylphosphonates 5a - d,g,h to phosphono-substituted heterocyclic compounds was studied.
