287107-84-0 Usage
Uses
Used in Pharmaceutical Industry:
(2S)-1-BOC-BETA-OXO-2-PIPERIDINEPROPANOIC ACID ETHYL ESTER is used as a key intermediate for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and BOC protecting group make it a valuable building block in the development of new drugs and agrochemicals.
Used in Medicinal Chemistry:
(2S)-1-BOC-BETA-OXO-2-PIPERIDINEPROPANOIC ACID ETHYL ESTER is used as a versatile building block in medicinal chemistry for the synthesis of bioactive molecules. Its piperidine ring structure and BOC protecting group contribute to the creation of diverse chemical entities with potential therapeutic applications.
Used in Organic Synthesis:
(2S)-1-BOC-BETA-OXO-2-PIPERIDINEPROPANOIC ACID ETHYL ESTER is used as a key component in organic synthesis for the development of new chemical entities. Its unique structure allows for the formation of various derivatives, expanding the scope of chemical research and innovation.
Check Digit Verification of cas no
The CAS Registry Mumber 287107-84-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,1,0 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 287107-84:
(8*2)+(7*8)+(6*7)+(5*1)+(4*0)+(3*7)+(2*8)+(1*4)=160
160 % 10 = 0
So 287107-84-0 is a valid CAS Registry Number.
287107-84-0Relevant academic research and scientific papers
Fu, Chunyan,He, Sudan,Li, Zhanhui,Lin, Yu,Luo, Lusong,Ma, Haikuo,Song, Shiwei,Tian, Sheng,Wang, Xu,Wang, Yujie,Wu, Shuwei,Zhang, Xiaohu,Zhao, Li,Zheng, Jiyue,Zhu, Fang
, (2020)
Chemokine receptor CXCR4 and its natural ligand CXCL12 (also known as stromal cell-derived factor-1, or SDF-1) regulate a broad range of physiological functions. Dysregulation of the CXCL12/CXCR4 axis is involved in numerous pathological conditions such as HIV infection, inflammation and cancer. Herein, we report the design, synthesis, and characterization of novel CXCR4 antagonists based on cyclic amine scaffolds. Compound 24 was identified as a potent CXCR4 receptor antagonist (competitive inhibition of 12G5 binding, IC50=24 nM; functional inhibition of CXCL12-induced cytosolic calcium increase, IC50=0.1 nM). In addition, compound 24 potently inhibited cell migration in CXCR4/CXCL12-mediated chemotaxis in a matrigel invasion assay. The absolute configuration of compound 24 was elucidated by X-ray crystallography.
