287174-29-2

Upstream product

• 141920-88-9 (1-Azido-2-phenyl-ethyl)-phosphonic acid diethyl ester 
• 124810-56-6 diethyl 1-hydroxy-2-phenylethylphosphonate 
• 287174-28-1 C₁₄H₂₆N₃O₃PSi₂ 

Downstream Products

• 287174-36-1 {2-[(1-azido-2-phenyl-ethyl)-(4-methanesulfonyl-benzyloxy)-phosphinoylsulfanyl]-ethoxy}-acetic acid tert-butyl ester 
• 287174-35-0 {2-[(1-azido-2-phenyl-ethyl)-(4-methanesulfonyl-benzyloxy)-phosphinoyloxy]-ethoxy}-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

A one-pot multistep approach to α-azido-phosphonate and phosphonothioate diesters: Key intermediates in the synthesis of haptens for the generation of antibody ligases

A four-step, one-pot synthesis of mixed α-azido-phosphonates and phosphonothioates 12a-d is described. This chemistry has provided a facile route to haptens 6a-b and 7 that have been employed for the elicitation of antibody ligases. Five hapten-specific antibodies have been identified as modest catalysts of a model peptide ligation reaction between thioester 1b and thiol 2 to give the amide product 5. (C) 2000 Elsevier Science Ltd. All rights reserved.