287174-35-0Relevant academic research and scientific papers
A one-pot multistep approach to α-azido-phosphonate and phosphonothioate diesters: Key intermediates in the synthesis of haptens for the generation of antibody ligases
Harwig, Curtis W.,Hoffman, Timothy Z.,Wentworth, Anita D.,Janda, Kim D.
, p. 915 - 918 (2007/10/03)
A four-step, one-pot synthesis of mixed α-azido-phosphonates and phosphonothioates 12a-d is described. This chemistry has provided a facile route to haptens 6a-b and 7 that have been employed for the elicitation of antibody ligases. Five hapten-specific antibodies have been identified as modest catalysts of a model peptide ligation reaction between thioester 1b and thiol 2 to give the amide product 5. (C) 2000 Elsevier Science Ltd. All rights reserved.
