141920-88-9

Upstream product

• 124810-56-6 diethyl 1-hydroxy-2-phenylethylphosphonate 

Downstream Products

• 77526-73-9 (1-Amino-2-phenylethyl)phosphonsaeure-diethylester 
• 287174-35-0 {2-[(1-azido-2-phenyl-ethyl)-(4-methanesulfonyl-benzyloxy)-phosphinoyloxy]-ethoxy}-acetic acid tert-butyl ester 
• 287174-36-1 {2-[(1-azido-2-phenyl-ethyl)-(4-methanesulfonyl-benzyloxy)-phosphinoylsulfanyl]-ethoxy}-acetic acid tert-butyl ester 
• 287174-29-2 C₈H₈Cl₂N₃OP 
• 66443-77-4 diethyl (1-(diethoxyphosphoryl)-2-phenylethyl)phosphoramidate 

Relevant academic research and scientific papers

An expedient synthesis of diethyl 1-azidoalkylphosphonates via the Mitsunobu reaction

Diethyl 1-azidoalkylphosphonates were obtained in high yield, and under mild conditions by the reaction of diethyl 1-hydroxyalkylphosphonates with hydrazoic acid in the presence of triphenylphosphine/diethyl azodicarboxylate (the Mitsunobu reaction).

Synthesis and antiproliferative activity of novel α- And β-dialkoxyphosphoryl isothiocyanates

A series of 15 mostly new dialkoxyphosphoryl alkyl and aralkyl isothiocyanates were synthesized using two alternative strategies, and their in vitro antiproliferative activity against several cancer cell lines (including drug resistant) is here demonstrat

A one-pot multistep approach to α-azido-phosphonate and phosphonothioate diesters: Key intermediates in the synthesis of haptens for the generation of antibody ligases

A four-step, one-pot synthesis of mixed α-azido-phosphonates and phosphonothioates 12a-d is described. This chemistry has provided a facile route to haptens 6a-b and 7 that have been employed for the elicitation of antibody ligases. Five hapten-specific antibodies have been identified as modest catalysts of a model peptide ligation reaction between thioester 1b and thiol 2 to give the amide product 5. (C) 2000 Elsevier Science Ltd. All rights reserved.

Application of 1-azidoalkylphosphonates in the synthesis of phosphonodipeptides and other N-substituted aminophosphonates

Efficient synthesis of diethyl 1-(isothiocyano)alkylphosphonates, and N-derivatives of diethyl 1-aminoalkylphosphonates as well as phosphonodipeptides were developed using diethyl 1-azidoalkylphosphonates as starting materials.

An efficient synthesis of diethyl 1-aminoalkylphosphonate hydrochlorides via the intermediate diethyl 1-azidoalkylphosphonates

The title compounds 4 have been obtained in high yields in a one-step sequence by the Mitsunobu reaction of diethyl 1-hydroxyalkylphosphonates 1 with hydrazoic acid, and subsequence treatment of the intermediate azides 2 with triphenylphosphine, followed