287174-32-7 Usage
Description
Hydroxy-PEG1-CH2CO2tBu is a PEG (polyethylene glycol) linker that features a hydroxyl group and a t-butyl protected carboxyl group. This molecule is designed to enhance solubility in aqueous environments due to the hydrophilic nature of the PEG spacer. The presence of the hydroxyl group allows for further chemical modifications, such as derivatization or the attachment of other reactive functional groups. Additionally, the t-butyl protected carboxyl group can be selectively removed under acidic conditions, revealing the free carboxyl group for further reactions or applications.
Uses
Used in Bioconjugation and Drug Delivery:
Hydroxy-PEG1-CH2CO2tBu serves as a versatile linker in bioconjugation processes, where it can be used to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The hydroxyl group facilitates these attachments, while the PEG spacer provides steric stabilization and improved solubility.
Used in Chemical Synthesis:
In chemical synthesis, Hydroxy-PEG1-CH2CO2tBu can be employed as an intermediate to produce a variety of PEGylated compounds. The t-butyl protected carboxyl group allows for selective deprotection, enabling the introduction of different functional groups or the formation of specific chemical bonds.
Used in Pharmaceutical Formulation:
Hydroxy-PEG1-CH2CO2tBu can be utilized in the formulation of pharmaceuticals to improve the solubility and stability of drug molecules. The PEG spacer can also provide a means to control the release of the drug, potentially enhancing the therapeutic efficacy and reducing side effects.
Used in Material Science:
In the field of material science, Hydroxy-PEG1-CH2CO2tBu can be incorporated into the design of hydrogels, polymers, or other materials to enhance their properties, such as biocompatibility, water solubility, and mechanical strength.
Used in Diagnostics:
Hydroxy-PEG1-CH2CO2tBu can be employed in the development of diagnostic tools, where it can be used to modify the surface of sensors or to create PEGylated contrast agents for imaging techniques, improving their performance and reducing non-specific interactions.
Overall, Hydroxy-PEG1-CH2CO2tBu is a multifunctional molecule with applications across various industries, including pharmaceuticals, diagnostics, material science, and chemical synthesis, due to its unique combination of properties and functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 287174-32-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,1,7 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 287174-32:
(8*2)+(7*8)+(6*7)+(5*1)+(4*7)+(3*4)+(2*3)+(1*2)=167
167 % 10 = 7
So 287174-32-7 is a valid CAS Registry Number.
287174-32-7Relevant articles and documents
Oseltamivir PROTAC compound as well as preparation method and application thereof in anti-influenza virus medicines
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Paragraph 0064-0068, (2021/04/03)
The invention discloses an oseltamivir PROTAC compound as well as a preparation method and application thereof in anti-influenza virus medicines, and belongs to the technical field of medicines. The oseltamivir PROTAC compound is shown as a general formula (I) or (II), and in the general formula, E3 ligase is a VHL or CRBN ligand, and Linker is a linking group. The compound provided by the invention can effectively degrade influenza virus neuraminidase so as to exert the activity of inhibiting influenza virus replication, not only has inhibitory activity on wild influenza viruses, but also hasa very good inhibitory effect on oseltamivir drug-resistant strains, and has low toxicity to cells. The compound or the pharmacologically or physiologically acceptable salt thereof can be used for preparing anti-influenza virus medicines.
Protein degradation targeting chimera for degrading androgen receptor
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Paragraph 0218-0220; 0227-0229, (2021/07/24)
The invention relates to a novel difunctional molecule compound based on VHL ligand induction and application of the difunctional molecule compound in synthesis of the compounds and pharmaceutical compositions thereof. The compound is shown as a formula I. The compound can selectively induce AR protein degradation and can be used for treating cancers such as prostatic cancer and breast cancer.
BIFUNCTIONAL SUBSTITUED PYRIMIDINES AS MODULATORS OF FAK PROTEOLYSE
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Paragraph 00416, (2020/02/16)
The present disclosure relates to bifunctional compounds, which find utility as modulators of focal adhesion kinase (FAK) or protein tyrosine kinase 2 (PTK2). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
