Hydroxy-PEG1-CH2CO2tBu

Base Information

• Chemical Name: Hydroxy-PEG1-CH2CO2tBu
• CAS No.: 287174-32-7
• Molecular Formula: C₈H₁₆O₄
• Molecular Weight: 176.213
• Hs Code.: 2942000090
• Mol file: 287174-32-7.mol

Synonyms:(2-hydroxyethoxy)acetic acid tert-butyl ester

Chemical Property of Hydroxy-PEG1-CH2CO2tBu

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hydroxy-PEG1-CH2CO2tBu ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Hydroxy-PEG1-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of Hydroxy-PEG1-CH2CO2tBu

There total 6 articles about Hydroxy-PEG1-CH2CO2tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(2-(benzyloxy)ethoxy)acetic acid tert-butyl ester (1309451-06-6) → (2-hydroxyethoxy)acetic acid tert-butyl ester (287174-32-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; under 1500.15 Torr;

DOI:10.1021/ic400227k

Reference yield: 67.0%

ethylene glycol (107-21-1) + t-butyl diazoacetate (35059-50-8) → (2-hydroxyethoxy)acetic acid tert-butyl ester (287174-32-7)

Guidance literature:

With dirhodium tetraacetate; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jacs.8b08008

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) + ethylene glycol (107-21-1) → (2-hydroxyethoxy)acetic acid tert-butyl ester (287174-32-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere; Cooling with ice;

upstream raw materials:

2-(2-(benzyloxy)ethoxy)acetic acid tert-butyl ester

bromoacetic acid tert-butyl ester

ethylene glycol

t-butyl diazoacetate

Downstream raw materials:

{2-[(1-azido-2-phenyl-ethyl)-(4-methanesulfonyl-benzyloxy)-phosphinoyloxy]-ethoxy}-acetic acid tert-butyl ester

tert-butyl 2-(2-[[(4-methylbenzene)sulfonyl]oxy]ethoxy)acetate

tert-butyl 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetate

tert-butyl 2-(2-aminoethoxy)acetate

Refernces

• 1、 -. "Protein degradation targeting chimera for degrading androgen receptor". Paragraph 0218-0220; 0227-0229. . Retrieved 2021/07/24.
• 2、 -. "DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF". Paragraph 000835. . Retrieved 2020/07/14.