7478-16-2

Usage

Family

Triazine

Substituents

Methoxy group ( \textOCH3 ) at the 3-position
Phenyl groups ( \textC6\textH5 ) at the 5 and 6 positions

Applications

Organic Synthesis: Used as a building block in organic synthesis.
Pharmaceutical Research: Employed in pharmaceutical research for synthesizing biologically active compounds.
Medicinal Chemistry and Drug Discovery: Potential applications in medicinal chemistry and drug discovery.

Properties

Reactivity: Exhibits reactivity suitable for the development of new drugs and materials.
Structure: Unique molecular structure contributing to its usefulness in scientific research and development.

Utility

Valuable tool in scientific research and development due to its interesting properties and structure.

Potential

Offers potential for the synthesis of various biologically active compounds.

Upstream product

• 67-56-1 methanol 
• 34177-11-2 3-chloro-5,6-diphenyl-1,2,4-triazine 
• 124-41-4 sodium methylate 
• 28735-33-3 5,6-diphenyl-3-methylthio-1,2,4-triazine 
• 134-81-6 benzil 

Downstream Products

• 857008-88-9 3-methoxy-5,6-diphenyl-1,4,5,6-tetrahydro-[1,2,4]triazine 
• 4512-00-9 5,6-diphenyl-1,2,4-triazin-3(2H)-one 
• 18510-97-9 2-methyl-5,6-diphenyl-1,2,4-triazin-3(2H)-one 
• 70299-25-1 3-methoxy-5,6-diphenyl-4,5-dihydro-[1,2,4]triazine 
• 132256-65-6 (5,6-Diphenyl-[1,2,4]triazin-3-yl)-phenyl-acetonitrile 
• 70299-25-1 3-methoxy-5,6-diphenyl-2,5-dihydro-1,2,4-triazine 
• 856861-04-6 2,4-diacetyl-5,6-diphenyl-tetrahydro-[1,2,4]triazin-3-one 
• 875238-92-9 2,4-diacetyl-5,6-diphenyl-4,5-dihydro-2H-[1,2,4]triazin-3-one 
• 74930-15-7 2-methyl-3-methoxy-5,6-diphenyl-2,5-dihydro-1,2,4-triazine 
• 37469-25-3 2-methyl-5,6-diphenyl-4,5-dihydro-1,2,4-triazin-3(2H)-one 

Relevant academic research and scientific papers

Synthesis and anti-inflammatory evaluation of 3-methylthio-1,2,4-triazines, 3-alkoxy-1,2,4-triazines, and 3-aryloxy-1,2,4-triazines

To develop nonacidic, nonsteroidal anti-inflammatory agents without GI complications, a series of asymmetric triazines was synthesized and evaluated for anti-inflammatory efficacy in the carrageenan-induced pedal edema assay. Toxicity was estimated by determination of approximate LD50 values in mice. 25 Compounds possessed activity comparable to the standard, indomethacin. Thirteen of the 25 compounds were selected for dose-response evaluation in the carrageenan assay based on their relative toxicity and anti-inflammatory activity. Neurotoxicity of the 13 triazines was estimated by determination of NTD50 values in mice. Five of the 13 compounds tested in the dose-response assay were active in terms of anti-inflammatory efficacy (ED50 values) and lack of overt neurotoxicity (NTD50 values) when compared to indomethacin. To determine the effect of these five developmental triazines on chronic inflammation, they were evaluated in the adjuvant-induced polyarthritis assay. One was comparable to indomethacin in reducing adjuvant-induced inflammation in this assay.

Pharmacologically active substituted 1,2,4-triazines

Substituted 1,2,4-triazines, compositions thereof and methods of using same are described. The compounds of the invention exhibit a wide range of pharmacological activity including anti-inflammatory, analgesic, anti-pyretic, hypotensive and central nervous system effects.