28737-33-9 Usage
Uses
Used in Pharmaceutical Research:
3-Bromoindole-2-carboxylic acid is used as a research compound for studying the effect of mimetic CDK9 inhibitors on HIV-1-activated transcription. This application is significant in the development of novel therapeutic strategies targeting the regulation of gene expression in HIV-1 infected cells, potentially leading to the discovery of new treatments for HIV/AIDS.
Used in Chemical Synthesis:
As a chemical intermediate, 3-bromoindole-2-carboxylic acid can be used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and reactivity make it a valuable building block for the creation of new molecules with potential applications in different industries.
Used in Material Science:
3-BROMOINDOLE-2-CARBOXYLIC ACID's properties may also find applications in material science, where it could be used to develop new materials with specific characteristics, such as light absorption, emission, or other optical properties. This could be particularly relevant in the development of advanced materials for electronics, photonics, or other high-tech applications.
Check Digit Verification of cas no
The CAS Registry Mumber 28737-33-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,7,3 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 28737-33:
(7*2)+(6*8)+(5*7)+(4*3)+(3*7)+(2*3)+(1*3)=139
139 % 10 = 9
So 28737-33-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H6BrNO2/c10-7-5-3-1-2-4-6(5)11-8(7)9(12)13/h1-4,11H,(H,12,13)/p-1
28737-33-9Relevant academic research and scientific papers
Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization
Song, Song,Sun, Xiang,Li, Xinwei,Yuan, Yizhi,Jiao, Ning
supporting information, p. 2886 - 2889 (2015/06/30)
An efficient and practical system for inexpensive bromination and iodination of arenes as well as heteroarenes by using readily available dimethyl sulfoxide (DMSO) and HX (X = Br, I) reagents is reported. This mild oxidative system demonstrates a versatile protocol for the synthesis of aryl halides. HX (X = Br, I) are employed as halogenating reagents when combined with DMSO which participates in the present chemistry as a mild and inexpensive oxidant. This oxidative system is amenable to late-stage bromination of natural products. The kilogram-scale experiment (>95% yield) shows great potential for industrial application.
CHEMICAL COMPOUNDS
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Page/Page column 88, (2009/01/24)
The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.
