95314-61-7

Upstream product

• 141-97-9 ethyl acetoacetate 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 612-23-7 2-nitrobenzyl chloride 

Downstream Products

• 16264-71-4 1-hydroxy-1H-indole-2-carboxylic acid 
• 41969-23-7 2-ethoxycarbonyl-1-hydroxyindole 
• 95314-52-6 C₁₉H₁₇N₄O₁₁^(1-)*C₆H₁₅N*H⁽¹⁺⁾ 
• 784-98-5 ethyl 2-nitrophenylpyruvate keto tautomer 
• 58532-79-9 3-methyl-4-(2-nitrobenzyl)-1-phenyl-1,4-dihydro-5H-pyrazol-5-one 
• 95314-51-5 C₁₉H₁₈N₄O₁₁ 
• 91348-45-7 3-bromo-1H-indole-2-carboxylic acid ethyl ester 
• 38343-91-8 3-chloro-1H-indole-2-carboxylic acid ethyl ester 
• 3770-50-1 2-carbethoxyindole 
• 28737-33-9 3-bromo-1H-indole-2-carboxylic acid 
• 28737-32-8 3-chloro-1H-indole-2-carboxylic acid 

Relevant academic research and scientific papers

Tandem catalytic oxidative deacetylation of acetoacetic esters and heteroaromatic cyclizations

One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(iii)/Co(ii) catalysts and the Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of ethyl acetoacetate to α,β-unsaturated carbonyl compounds. The oxidative deacetylation and reductive cyclization of β-ketoesters derived from ethyl acetoacetate and o-nitrobenzyl bromides efficiently produced diversely substituted indoles. This journal is

ISOXAZOLIN-5-ONE DERIVATIVES AND HERBICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS

An isoxazolin-5-one derivative represented by formula (1) below: wherein R1 represents a C1-C6 haloalkyl group, Q represents a C3-C8 cycloalkyl group substituted with a C1-C6 alkoxy group, each of R2, R3 and X represents a certain substituent or the like, and n represents an integer of 1 to 4, wherein X's may be different from each other when n represents an integer of 2 to 4, and a herbicide containing the isoxazolin-5-one derivative as an active ingredient are provided.

ISOXAZOLIN-5-ONE DERIVATIVE AND HERBICIDE CONTAINING SAME AS ACTIVE INGREDIENT

An isoxazolin-5-one derivative represented by the following (1): wherein R1 represents a C1-C6 haloalkyl group, and R2 to R4 and X each represents a certain substituent or the like; and n represents an integer of 1 to 4, wherein X's may be different from each other when n represents an integer of 2 to 4, and an herbicide containing the isoxazolin-5-one derivative as an active ingredient are provided.

SYNTHESIS OF INDOLES FROM ACETOACETIC ESTERS

The present invention relates to a synthesizing method of indole using acetoacetic ester and, more specifically, to a synthesizing method of indole which induces reduction of a nitro group into an amine group and aromatic cyclization with a ketone group through hydrogenation using a metal catalyst in a 2-nitrobenzyl ketone compound, after synthesizing the 2-nitrobenzyl ketone compound through deacetylation using a manganese (III) / cobalt (II) catalyst in a 2-nitrobenzyl acetone compound obtained by adding an acetoacetic ester compound in a 2-nitrobenzyl bromide compound.COPYRIGHT KIPO 2016

TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE

The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.

Alkynylation of heterocyclic compounds using hypervalent iodine reagent

The alkynylation of various nitrogen- and/or sulphur-containing heterocyclic compounds using hypervalent iodine TMS-EBX by utilization of tertiary amines under mild conditions is described. The developed metal-free methodology furnishes the corresponding alkynylated heterocycles bearing quaternary carbon in high yields.

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from -N= etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from -CH 2 - etc., and R 2 is selected from C 1-6 alkyl etc.

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from -N= etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from -CH2- etc., and R2 is selected from C1-6 alkyl etc.

NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY

The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from -N= etc., Y3 and Y4 are selected from -CH= etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.