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287383-59-9

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Product FOB Price Min.Order Supply Ability Supplier
Scriptaid
Cas No: 287383-59-9
No Data No Data No Data Beijing Jin Ming Biotechnology Co., Ltd. Contact Supplier
6-(1,3-DIOXO-1H-BENZO[DE]ISOQUINOLIN-2(3H)-YL)-N-HYDROXYHEXANAMIDE
Cas No: 287383-59-9
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Factory Price API 99% SCRIPTAID 287383-59-9 GMP Manufacturer
Cas No: 287383-59-9
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
cyclohexyl-(4-methylphenyl)methanone
Cas No: 287383-59-9
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
1H-Benz[de]isoquinoline-2(3H)-hexanamide,N-hydroxy-1,3-dioxo-
Cas No: 287383-59-9
No Data No Data 10000 Metric Ton/Month Henan Wentao Chemical Product Co., Ltd. Contact Supplier
Scriptaid
Cas No: 287383-59-9
No Data 1 Gram 1000 Gram/Week Shanghai BetterBioChem Co., Ltd. Contact Supplier
Scriptaid 287383-59-9
Cas No: 287383-59-9
No Data 1 Gram 100 Gram/Month Taizhou Crene Biotechnology co.ltd Contact Supplier
1H-Benz[de]isoquinoline-2(3H)-hexanamide,N-hydroxy-1,3-dioxo-
Cas No: 287383-59-9
No Data No Data 5 Hangzhou J&H Chemical Co., Ltd. Contact Supplier
Scriptaid;GCK1026;1H-Benz[de]isoquinoline-2(3H)-hexanamide,N-hydroxy-1,3-dioxo-
Cas No: 287383-59-9
No Data 1 Milligram 5 Xiamen Jenny Chemical Technology Co., Ltd. Contact Supplier
SAGECHEM/Scriptaid (GCK 1026/SAGECHEM/Manufacturer in China
Cas No: 287383-59-9
No Data No Data No Data SAGECHEM LIMITED Contact Supplier

287383-59-9 Usage

Description

Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems.1 It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo.2,3 Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.4

Uses

Scriptaid has been used in post activation of oocytes and embryo culture.

Uses

Histone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.

General Description

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

Biological Activity

Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.

Biochem/physiol Actions

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.

References

1) Su?et al.?(2000),?A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library; Cancer Res.,?60?3137 2) Huber?et al.?(2011),?Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells; J. Biol. Chem.,?286?22211 3) Lee?et al.?(2008),?Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells; J. Oncol.,?33?767 4) Rissi?et al.?(2019),?Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos; Reproduction,?157?123 5) Huang?et al.?(2020),?Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin; J. Appl. Physiol.,?128?276
InChI:InChI=1/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)

287383-59-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide

1.2 Other means of identification

Product number -
Other names GNF-PF-2024

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:287383-59-9 SDS

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