287393-40-2

Basic information

• Product Name: Benzeneacetic acid, a-[[4-(2-butynyloxy)phenyl]thio]-, ethyl ester
• CAS NO: 287393-40-2
• Molecular Formula: C20H20O3S
• Molecular Weight: 340.443
• Mol File: 287393-40-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-[[4-(2-butynyloxy)phenyl]thio]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-[[4-(2-butynyloxy)phenyl]thio]-, ethyl ester(287393-40-2)
• EPA Substance Registry System: Benzeneacetic acid, a-[[4-(2-butynyloxy)phenyl]thio]-, ethyl ester(287393-40-2)

Safety Data

• Hazardous Substances Data: 287393-40-2(Hazardous Substances Data)

Upstream product

• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 637-89-8 4-sulfanylphenol 
• 3355-28-0 1-Bromo-2-butyne 
• 287393-39-9 ethyl phenyl [4-(hydroxyphenyl)sulfanyl]acetate 

Downstream Products

• 287393-41-3 {[4-(2-butynyloxy)phenyl]sulfanyl}(phenyl)acetic acid 
• 819054-97-2 ethyl-{[4-(2-butynyloxy)phenyl]sulfonyl}(phenyl)acetate 
• 287392-54-5 2-{[4-(2-Butynyloxy)phenyl]sulfanyl}-2-phenyl-N-hydroxyacetamide 
• 819054-98-3 {[4-(2-butynyloxy)phenyl]sulfonyl}(phenyl)acetic acid 

Relevant articles and documents

Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-α converting enzyme and matrix metalloproteinase inhibitors

A series of 4-alkynyloxy phenyl sulfanyl, sulfinyl and sulfony alkyl and piperidine-4-carboxylic acid hydroxamides were synthesized. Their structure-activity relationships, against tumor necrosis factor-α (TACE) and matrix metalloproteinase (MMP) inhibito

Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors

Compounds of the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.