287397-89-1Relevant academic research and scientific papers
Stable isotope-labeled chlorpyrifos-d10 and synthesis method thereof
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Paragraph 0029; 0034, (2020/12/15)
The invention discloses stable isotope-labeled chlorpyrifos-d10 and a synthesis method thereof. The synthesis method includes the steps: making stable isotope labeled ethyl alcohol-d10 as a stable isotope labeling source react with phosphorus pentasulfide to obtain stable isotope-labeled o, o-diethylphosphorothioate, making the stable isotope-labeled o, o-diethylphosphorothioate and 3, 5, 6-trichloro-2-pyridinol sodium salt undergo a condensation reaction to obtain the stable isotope labeled chlorpyrifos-d10 product. The stable isotope labeling raw material used in the method is ethanol-d10, the source is easy to obtain, the price is low, the synthesis process is simple and easy to operate, the product is simple and convenient to separate and purify, the chemical purity and isotope abundance of the obtained product can reach 98% or above, and the related requirements of a standard reagent for quantitatively detecting the chlorpyrifos content are met.
Synthesis of (diethyl-d10) coumaphos and related compounds
Kochansky, Jan
, p. 2826 - 2828 (2007/10/03)
Two deuterated insecticides were prepared for use as internal standards for gas-liquid chromatographic-mass spectrometric analyses. Diethyl chlorothiophosphate-d10 was prepared by reaction of ethanol-d6 with P2S5 to give labeled diethyldithiophosphoric acid, followed by chlorination. Treatment of the acid chloride with 3-chloro-4-methyl-7-hydroxycoumarin and potassium carbonate in acetone at reflux gave labeled coumaphos. An analogous reaction with 4-methyl-7-hydroxycoumarin gave labeled potasan, and the technique should be usable for synthesis of labeled forms of other dialkyl thiophosphate insecticides.
