287397-89-1Relevant articles and documents
Stable isotope-labeled chlorpyrifos-d10 and synthesis method thereof
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Paragraph 0029; 0034, (2020/12/15)
The invention discloses stable isotope-labeled chlorpyrifos-d10 and a synthesis method thereof. The synthesis method includes the steps: making stable isotope labeled ethyl alcohol-d10 as a stable isotope labeling source react with phosphorus pentasulfide to obtain stable isotope-labeled o, o-diethylphosphorothioate, making the stable isotope-labeled o, o-diethylphosphorothioate and 3, 5, 6-trichloro-2-pyridinol sodium salt undergo a condensation reaction to obtain the stable isotope labeled chlorpyrifos-d10 product. The stable isotope labeling raw material used in the method is ethanol-d10, the source is easy to obtain, the price is low, the synthesis process is simple and easy to operate, the product is simple and convenient to separate and purify, the chemical purity and isotope abundance of the obtained product can reach 98% or above, and the related requirements of a standard reagent for quantitatively detecting the chlorpyrifos content are met.