287399-61-5Relevant academic research and scientific papers
Benzamide derivatives and drugs containing the same
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, (2008/06/13)
A novel benzamide derivative represented by the following general formula: wherein R represents an alkyl group having 3 to 6 carbon atoms or a salt thereof, and a medicament comprising said derivative as an active ingredient. The medicament has excellent
An improved synthesis of butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate (AU-224)
Sakaguchi, Jun,Higashi, Taijiro,Azuma, Takahiro,Suzuki, Tomio,Iwasaki, Nobuhiko,Kondo, Noriyuki,Nagata, Osamu,Kato, Hideo,Hanaoka, Miyoji
, p. 788 - 790 (2007/10/03)
A new and facile route for the synthesis of the novel gastrointestinal prokinetic butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate (1b), which exhibited potent gastro- and colon-prokinetic activities by oral administration without significant side effects, was established. The key intermediate, butyl 4-amino-1-piperidineacetate (16), was prepared from commercially available 4-amino-1-benzylpiperidine (2) in a high yield with four steps. Compound 1b was prepared by condensation of commercially available 4-amino-5-choloro-2-methoxybenzoic acid (7) with 16 in 84% yield. This improved synthetic route was appropriate for large-scale synthesis of 1b.
