2874-73-9

Usage

Uses

Used in Chemical Industry:
2,2-Dimethyldodecanoic acid is utilized as an intermediate for the synthesis of various organic compounds, playing a crucial role in the development of new chemical products.
Used in Synthetic Lubricants Production:
It is employed as a component in the production of synthetic lubricants, where its high thermal stability and resistance to oxidation are highly beneficial for enhancing the performance and longevity of the lubricants.
Used in Plasticizers Production:
2,2-Dimethyldodecanoic acid is used in the creation of plasticizers, which are additives that increase the flexibility and workability of plastics, making them more suitable for various applications.
Used in Corrosion Inhibitors Production:
It serves as a component in the formulation of corrosion inhibitors, which are essential in protecting materials from the damaging effects of corrosion, thereby extending their service life.
Used in Cosmetic Industry:
Due to its ability to modify the physical and chemical properties of formulations, 2,2-Dimethyldodecanoic acid has potential applications in the cosmetic industry, where it can contribute to the development of more effective and stable products.
Used in Pharmaceutical Industry:
Similarly, in the pharmaceutical sector, 2,2-Dimethyldodecanoic acid can be used to enhance the properties of drug formulations, potentially leading to improved efficacy and stability of medications.

InChI:InChI=1/C14H28O2/c1-4-5-6-7-8-9-10-11-12-14(2,3)13(15)16/h4-12H2,1-3H3,(H,15,16)

Upstream product

• 872-05-9 1-Decene 
• 79-31-2 isobutyric Acid 
• 112-29-8 1-bromo dodecane 
• 858270-11-8 4-(1,1-dimethyl-undecyl)-pyrocatechol 
• 67-64-1 acetone 
• 32361-41-4 methyl 2,2-dimethyldodecanoate 
• 74830-50-5 acide peroxydimethyl-2,2 dodecanoique 
• 201230-82-2 carbon monoxide 
• 14593-46-5 sodium tert-pentoxide 
• 76402-83-0 2-Bromo-2-methyldodecane 
• 4325-53-5 2-chloro-2-methyldodecane 

Downstream Products

• 140112-94-3 [2-(2,2-Dimethyl-dodecanoylamino)-3,5-dimethoxy-phenoxy]-acetic acid methyl ester 
• 140112-95-4 [2-(2,2-Dimethyl-dodecanoylamino)-3,5-dimethoxy-phenoxy]-acetic acid 
• 140112-96-5 2,2-Dimethyl-dodecanoic acid (2-heptyloxy-4,6-dimethoxy-phenyl)-amide 
• 140112-86-3 3-(2,2-Dimethyl-dodecanoylamino)-4-methoxy-benzoic acid methyl ester 
• 114289-47-3 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide 
• 140112-93-2 2,2-Dimethyl-dodecanoic acid (2-hydroxy-4,6-dimethoxy-phenyl)-amide 
• 140112-91-0 2,2-Dimethyl-dodecanoic acid (2,4,6-trifluoro-phenyl)-amide 
• 114289-41-7 N-[2,6-bis(1-methylethyl)phenyl]-2,2-dimethyldodecanamide 
• 114289-42-8 N-(2-Ethoxy-6-methylphenyl)-2,2-dimethyl-dodecanamide 
• 140112-92-1 2,2-Dimethyl-dodecanoic acid (4-bromo-2,6-dimethyl-phenyl)-amide 
• 140112-88-5 2,2-Dimethyl-dodecanoic acid (2-methoxy-6-methyl-phenyl)-amide 
• 114289-40-6 N-(2,6-diethylphenyl)-2,2-dimethyldodecanamide 
• 140112-90-9 2,2-Dimethyl-dodecanoic acid (2,4,6-trimethyl-phenyl)-amide 
• 140112-87-4 2,2-Dimethyl-dodecanoic acid (2-chloro-6-methyl-phenyl)-amide 

Relevant academic research and scientific papers

Development of small-molecule inhibitors of fatty acyl-AMP and fatty acyl-CoA ligases in Mycobacterium tuberculosis

Lipid metabolism in Mycobacterium tuberculosis (Mtb) relies on 34 fatty acid adenylating enzymes (FadDs) that can be grouped into two classes: fatty acyl-CoA ligases (FACLs) involved in lipid and cholesterol catabolism and long chain fatty acyl-AMP ligases (FAALs) involved in biosynthesis of the numerous essential and virulence-conferring lipids found in Mtb. The precise biochemical roles of many FACLs remain poorly characterized while the functionally non-redundant FAALs are much better understood. Here we describe the systematic investigation of 5′-O-[N-(alkanoyl)sulfamoyl]adenosine (alkanoyl adenosine monosulfamate, alkanoyl-AMS) analogs as potential multitarget FadD inhibitors for their antitubercular activity and biochemical selectivity towards representative FAAL and FACL enzymes. We identified several potent compounds including 12-azidododecanoyl-AMS 28, 11-phenoxyundecanoyl-AMS 32, and nonyloxyacetyl-AMS 36 with minimum inhibitory concentrations (MICs) against M. tuberculosis ranging from 0.098 to 3.13 μM. Compound 32 was notable for its impressive biochemical selectivity against FAAL28 (apparent Ki = 0.7 μM) versus FACL19 (Ki > 100 μM), and uniform activity against a panel of multidrug and extensively drug-resistant TB strains with MICs ranging from 3.13 to 12.5 μM in minimal (GAST) and rich (7H9) media. The SAR analysis provided valuable insights for further optimization of 32 and also identified limitations to overcome.

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Phenol compound having antioxidative activity and the process for preparing the same

Disclosed are a phenol compound represented by the formula (1): STR1 wherein R0 represents H, alkyl or alkyloxy; R1 represents alkyl; R2 represents alkyl or alkyloxy; OR3 represents OH; R4 represents H, lower alkyl or acyl, each of the above substituents may be substituted; W represents O, S or NR7 ; where R7 represents H, alkyl, aryl, OH or alkyloxy, a group of the formula (2): STR2 represents an amino which may be mono- or di-substituted or heterocyclic group containing N atom, or a pharmaceutically acceptable salt thereof, and a process for preparing the same.

Inhibitors of Acyl-CoA:cholesterol acyltransferase. I. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents

A series of fatty acid anilides was prepared, and compounds were tested for their ability to inhibit the enzyme acyl-CoA:cholesterol acyltransferase (ACAT) in vitro and to lower plasma total cholesterol and elevate high- density lipoprotein cholesterol in cholesterol-fed rats in vivo. The compounds reported were found to fall into two subclasses with different anilide SAR. For nonbranched acyl analogues, inhibitory potency was found to be optimal with bulky 2,6-dialkyl substitution. For α-substituted acyl analogues, there was little dependence of in vitro potency on anilide substitution and 2,4,6-trimethoxy was uniquely preferred. Most of the potent inhibitors (IC50 50 nM) were found to produce significant reductions in plasma total cholesterol in cholesterol-fed rats. Additionally, in vivo activity could be improved significantly by the introduction of α,α- disubstitution into the fatty acid portion of the molecule. A narrow group of α,α-disubstituted trimethoxyanilides, exemplified by 2,2-dimethyl-N-(2,4,6- trimethoxyphenyl)dodecanamide (39), was found to not only lower plasma total cholesterol (-60%) in cholesterol-fed rats but also elevate levels of high- density lipoprotein cholesterol (+94%) in this model at the screening dose of 0.05% in the diet (ca. 50 mg/kg).

ETUDE DU CARACTERE NUCLEOPHILE DES RADICAUX LORS DE LA REACTION DE TRANSFERT SUR LA LIAISON O-O DES PERACIDES

Peracids RCO3H yield free radicals R. which react either with the peracid or with solvent giving the alcohol ROH and the hydrocarbon RH.The nucleophilic character of the free radicals was modified either by substitution of the carbon bearing the odd electron by inductive groups or by changing the free radical hybridation by the means of blocked structures such as cyclic or bicyclic free radicals.For each R., the measurement of the ratio ROH/RH establishes a reactivity scale for R. with the peracid O-O bond.This reactivity does not depend on free radical stability but depends strongly on nucleophilic character.A primary free radical is less reactive than a secondary one, and is much less reactive than a tertiary one.A bridgehead free radical as the bicycloheptyle-1 does not react with the peracid.These results are interpreted to indicate a transition state with charge transfer (polar effect), the peracid being electrophilic and the free radical nucleophilic; PMO theory is discussed.