287407-08-3

Upstream product

• 2450-71-7 Propargylamine 
• 287407-07-2 tert-butyl 2-(4-fluoro-N-methylphenylsulfonamido)acetate 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 213015-69-1 tert-butyl 2-{[(4-fluorophenyl)sulfonyl]amino}acetate 
• 13029-71-5 2-(4-fluorophenylsulfonamido)acetic acid 

Downstream Products

• 287407-09-4 2-(methyl{[4-(prop-2-ynylamino)phenyl]sulfonyl}-amino)acetic acid 

Relevant academic research and scientific papers

ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS

Compound of the formula (B) are useful in treating disease conditions mediated by TNF- alpha , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamates

The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors, all bearing a butynyloxy P1′ group, was explored. In particular, compound 5j has excellent in vitro potency against isolated TACE enzyme and in cells, good selectivity over MMP-1 and MMP-9, and oral activity in an in vivo model of TNF-α production and a collagen-induced arthritis model.

Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors

Compounds of the formula: are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.