287477-26-3Relevant academic research and scientific papers
Ruthenium-catalyzed asymmetric hydrogenation of N-Boc-indoles
Kuwano, Ryoichi,Kashiwabara, Manabu
, p. 2653 - 2655 (2007/10/03)
Highly enantioselective hydrogenation of various N-Boc-indoles proceeded successfully in the presence of the ruthenium complex generated from an appropriate ruthenium precursor and a trans-chelate chiral bisphosphine PhTRAP. Various 2- or 3-substituted indoles were converted into chiral indolines with high enantiomeric excesses (up to 95% ee). The PhTRAP-ruthenium catalyst was able to promote the hydrogenation of 2,3-dimethylindoles, giving cis-2,3-dimethylindolines with 72% ee.
Ethynylbenzene compounds and derivatives thereof in the treatment of pain, fever or inflammation
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, (2008/06/13)
A method of treating inflammation, pain or fever in a warm blooded animal by administering an effective amount of a compound which is a cyano ethynylbenzene, and the pharmaceutical preparation thereof.
Ethynylbenzene compounds and derivatives thereof
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, (2008/06/13)
Novel ethynylbenzene compounds and derivatives are described. Their use in the treatment of inflammation is also disclosed.
