287490-80-6Relevant academic research and scientific papers
2-(3-pyridyl)thiazolidine-4-carboxamide derivatives. II. Structure- activity relationships and active configuration of 2-(3- pyridyl)thiazolidine-4-carboxamides as platelet-activating factor receptor antagonists
Suzuki, Takeshi,Nagaoka, Hitoshi,Kondo, Yutaka,Takahashi, Takumi,Takeuchi, Makoto,Hara, Hiromu,Saito, Munetoshi,Yamada, Toshimitsu,Tomioka, Kenichi,Hamada, Mamoru,Mase, Toshiyasu
, p. 1468 - 1473 (1998)
Conversion of the 2-(3-pyridyl)thiazolidine part of 1-(3-phenylpropyl)- 4-[2-(3-pyridyl)thiazolidine-4-carbonyl]piperazine (YM461), which is a potent platelet-activating factor (PAF) antagonist, to other rings was performed, and PAF antagonistic activitie
Discovery of cysteine and its derivatives as novel antiviral and antifungal agents
Lu, Aidang,Shi, Li,Wang, Tienan,Wang, Ziwen,Yang, Shan,Zhou, Yanan
, (2021/06/25)
Based on the structure of the natural product cysteine, a series of thiazolidine-4-carboxylic acids were designed and synthesized. All target compounds bearing thiazolidine-4-carboxylic acid were characterized by1 H-NMR,13 C-NMR, and
An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics
Espeland, Ludvik Olai,Georgiou, Charis,Klein, Raphael,Bhukya, Hemalatha,Haug, Bengt Erik,Underhaug, Jarl,Mainkar, Prathama S.,Brenk, Ruth
supporting information, p. 2715 - 2726 (2021/08/12)
FabF (3-oxoacyl-[acyl-carrier-protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from P. aeruginosa (PaFabF) as antibiot
AMIDO ANTI-VIRAL COMPOUNDS
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Page/Page column 91; 112-113, (2008/12/05)
Disclosed are compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof of having Formula (I), their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R3, X, V, W, T, Z, R, Y1, and p are as defined herein.
Synthesis and Chiroptical Properties of N-Acetyl-2-aryl-4-thiazolidinecarboxylic Acids
Gyoergydeak, Zoltan,Kajtar-Peredy, Maria,Kajtar, Judit,Kajtar, Marton
, p. 927 - 934 (2007/10/02)
(4R)-2-Aryl-4-thiazolidinecarboxylic acids 3, derived from aromatic aldehydes 1 and L-cysteine (2), could be diastereoselectively converted into (2R,4R)- or (2S,4R)-N-acetyl-2-aryl-4-thiazolidinecarboxylic acids (4 and 5, resp.).The diastereomers can be d
2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity
Nagasawa,Goon,Muldoon,Zera
, p. 591 - 596 (2007/10/02)
A number of 2-alkyl- and 2-aryl-substituted thiazolidine-4(R)-carboxylic acids were evaluated for their protective effect against hepatotoxic deaths produced in mice by LD90 doses of acetaminophen. 2(RS)-Methyl-(1b),2(RS)-n-propyl-, and 2(RS)-n
