28771-82-6

Basic information

• Product Name: 5-BROMO-4-METHYL-2-PHENYL-1,3-THIAZOLE
• Synonyms: 5-BROMO-4-METHYL-2-PHENYL-1,3-THIAZOLE;(5-Bromo-4-methyl-1,3-thiazol-2-yl)benzene
• CAS NO: 28771-82-6
• Molecular Formula: C₁₀H₈BrNS
• Molecular Weight: 254.15
• Product Categories: Halides;Thiazoles, Isothiazoles &Benzothiazoles;Thiazoles, Isothiazoles & Benzothiazoles
• Mol File: 28771-82-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 60 °C
• Boiling Point: 351°Cat760mmHg
• Flash Point: 166.1°C
• Appearance: /
• Density: 1.496g/cm³
• Vapor Pressure: 8.59E-05mmHg at 25°C
• Refractive Index: 1.622
• PKA: 1.98±0.10(Predicted)
• Sensitive: Stench
• CAS DataBase Reference: 5-BROMO-4-METHYL-2-PHENYL-1,3-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-4-METHYL-2-PHENYL-1,3-THIAZOLE(28771-82-6)
• EPA Substance Registry System: 5-BROMO-4-METHYL-2-PHENYL-1,3-THIAZOLE(28771-82-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 28771-82-6(Hazardous Substances Data)

Usage

General Description

5-Bromo-4-methyl-2-phenyl-1,3-thiazole is a heterocyclic compound with a thiazole ring containing a bromine atom, a methyl group, and a phenyl group. It is a chemical with potential applications in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules. 5-BROMO-4-METHYL-2-PHENYL-1,3-THIAZOLE has been studied for its potential anti-cancer, anti-inflammatory, and antimicrobial properties. Its unique structure makes it an important intermediate in the production of pharmaceuticals and other organic compounds. Additionally, it can also be used as a reagent in organic synthesis and chemical research.

InChI:InChI=1/C10H8BrNS/c1-7-9(11)13-10(12-7)8-5-3-2-4-6-8/h2-6H,1H3

Upstream product

• 1826-17-1 4-methyl-2-phenyl-thiazole 
• 100-52-7 benzaldehyde 
• 90923-62-9 4-methyl-2-phenyl-2,5-dihydro-thiazole 

Downstream Products

• 1826-17-1 4-methyl-2-phenyl-thiazole 
• 83247-14-7 trans-2-Phenyl-4-methyl-5-styrylthiazole 
• 111601-10-6 (Z)-3-(4-Methyl-2-phenyl-thiazol-5-yl)-acrylonitrile 
• 111601-09-3 (E)-3-(4-Methyl-2-phenyl-thiazol-5-yl)-acrylonitrile 
• 111601-08-2 (E)-3-(4-Methyl-2-phenyl-thiazol-5-yl)-acrylic acid ethyl ester 
• 111600-94-3 5-ethynyl-4-methyl-2-phenylthiazole 
• 141062-96-6 1,2-bis(4-methyl-2-phenylthiazol-5-yl)hexafluoro-1-cyclopentene 
• 1021432-61-0 5-cyclopropyl-4-methyl-2-phenyl-1,3-thiazole 
• 1314325-29-5 (R)-2-(4-methyl-2-Phenylthiazol-5-yl)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1279106-42-1 2-(2-chloro-phenylethynyl)-4-(4-methyl-2-phenyl-thiazol-5-yl)-phenylamine 
• 1279106-41-0 2-bromo-4-(4-methyl-2-phenyl-thiazol-5-yl)-phenylamine 
• 1279103-47-7 2-(2-chloro-phenyl)-5-(4-methyl-2-phenyl-thiazol-5-yl)-1H-indole 
• 1279106-43-2 5-(4-Methyl-2-phenyl-thiazol-5-yl)-1,3-dihydro-indol-2-one 
• 1279106-40-9 4-(4-methyl-2-phenyl-thiazol-5-yl)-phenylamine 

Relevant articles and documents

IMIDAZOPYRIDAZINE COMPOUNDS

The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.

N-Bromosuccinimide Bromination of Substituted Methylthiazoles

Bromination of methylthiazoles with one unsubstituted position by N-bromosuccinimide may take place either at the methyl group, at the heterocyclic nucleus, or at both positions according to the nature of the second substituent.The ethoxycarbonyl group in the compounds 1a-3a directs the bromine into the side chain.So it is possible to obtain the tribromomethyl compounds 1d and 2d without bromination of the thiazole nucleus.In the phenyl-substituted methylthiazoles 4a-6a bromination takes place in the methyl group and in the heterocyclic nucleus. - The bromomethylthiazoles 1b-3b yield the vinylthiazoles 1k-3k by Wittig reaction.