287717-24-2

Upstream product

• 134916-00-0 (4S)-4-benzyl-3-(hex-5-enoyl)-1,3-oxazolidin-2-one 
• 109-80-8 1.3-propanedithiol 
• 273753-64-3 1-(4(S)-Benzyl-2-oxo-oxazolidin-3-yl)-hexane-1,5-dione 

Downstream Products

• 382139-11-9 C₆₀H₈₉N₅O₁₂ 
• 382139-09-5 C₄₃H₅₉IN₄O₁₀ 
• 428874-22-0 3-(3-tert-butoxycarbonyloxy-phenyl)-2-(2-{[3-(6-hydroxy-8-iodo-7-methyl-octa-1,3,7-trienyl)-1,4-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonane-6-carbonyl]-amino}-3-methyl-butyrylamino)-propionic acid 2-trimethylsilanyl-ethyl ester 
• 382139-10-8 C₃₈H₅₁IN₄O₈ 
• 382139-23-3 1-[3-(3-tert-butoxycarbonyloxy-phenyl)-2-(2-{[3-(6-hydroxy-8-iodo-7-methyl-octa-1,3,7-trienyl)-1,4-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonane-6-carbonyl]-amino}-3-methyl-butyrylamino)-propionyl]-hexahydro-pyridazine-3-carboxylic acid 
• 382139-08-4 1-[3-(3-tert-butoxycarbonyloxy-phenyl)-2-(2-{[3-(6-hydroxy-8-iodo-7-methyl-octa-1,3,7-trienyl)-1,4-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonane-6-carbonyl]-amino}-3-methyl-butyrylamino)-propionyl]-hexahydro-pyridazine-3-carboxylic acid methyl ester 
• 287717-29-7 (S)-4-Benzyl-3-{(6E,8E)-(2R,3R,4S,5S,11S)-11-(tert-butyl-diphenyl-silanyloxy)-3,5-dihydroxy-4-methyl-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-trideca-6,8-dien-12-ynoyl}-oxazolidin-2-one 
• 287717-28-6 (6E,8E)-(2R,4S,5S,11S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-11-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-4-methyl-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-trideca-6,8-dien-12-yne-1,3-dione 
• 1026273-04-0 (6E,8E,12E)-(2R,4S,5S,11S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-11-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-13-iodo-4,12-dimethyl-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-trideca-6,8,12-triene-1,3-dione 
• 287717-36-6 (S)-4-Benzyl-3-{(6E,8E,12E)-(2R,3R,4S,5S,11S)-11-(tert-butyl-dimethyl-silanyloxy)-3,5-dihydroxy-13-iodo-4,12-dimethyl-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-trideca-6,8,12-trienoyl}-oxazolidin-2-one 
• 428874-13-9 (S)-4-Benzyl-3-{(3S,4S,5R,6R)-3-[(1E,3E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-octa-1,3-dien-7-ynyl]-1,4-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonane-6-carbonyl}-oxazolidin-2-one 
• 428874-15-1 (S)-4-Benzyl-3-{(3S,4S,5R,6R)-3-[(1E,3E,7E)-(S)-6-(tert-butyl-dimethyl-silanyloxy)-8-iodo-7-methyl-octa-1,3,7-trienyl]-1,4-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonane-6-carbonyl}-oxazolidin-2-one 
• 187148-13-6 (-)-sanglifehrin A 
• 287717-25-3 (R)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-2-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-pentane-1,3-dione 

Relevant academic research and scientific papers

A convergent three-component total synthesis of the powerful immunosuppressant (-)-sanglifehrin A

The potent immunosuppressive agent (-)-sanglifehrin A (5), initially discovered in a soil sample from Malawi, has been synthesized in a highly conver soil gent and stereocontrolled manner. The enantioselective approach relies on initial construction of th

Highly diastereocontrolled synthesis of the C1-C25 domain of sanglifehrin A

We report a diastereoselective synthesis of 2 containing the core structure of the entire eastern sector of sanglifehrin A. The route proceeds by directed chain extension of appropriate building blocks, their timely convergent amalgamation, and ultimate c