28783-51-9 Usage
Description
2-CHLOROMETHYLENE-MALONIC ACID DIETHYL ESTER is a diethyl ester derivative of malonic acid, featuring a chloromethylene group. It is a colorless liquid with a slightly fruity odor, used extensively in organic synthesis and medicinal chemistry. This chemical compound is typically handled and stored under inert gas to prevent degradation, and due to its toxic nature, it requires careful handling in laboratory settings.
Uses
Used in Organic Synthesis:
2-CHLOROMETHYLENE-MALONIC ACID DIETHYL ESTER is used as a reagent for the synthesis of various organic compounds, leveraging its unique structural features to facilitate chemical reactions and form new molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-CHLOROMETHYLENE-MALONIC ACID DIETHYL ESTER is utilized as a key intermediate in the development of pharmaceuticals. Its properties allow it to be incorporated into drug molecules, potentially enhancing their therapeutic effects.
Used in Pharmaceutical Industry:
2-CHLOROMETHYLENE-MALONIC ACID DIETHYL ESTER is used as a building block in the creation of new pharmaceuticals, contributing to the discovery and synthesis of novel drug candidates for various medical conditions.
Used in Agrochemical Industry:
2-CHLOROMETHYLENE-MALONIC ACID DIETHYL ESTER is also used as a reagent in the synthesis of agrochemicals, such as pesticides and herbicides, where its chemical properties can be harnessed to develop more effective and targeted products for agricultural use.
Check Digit Verification of cas no
The CAS Registry Mumber 28783-51-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,7,8 and 3 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 28783-51:
(7*2)+(6*8)+(5*7)+(4*8)+(3*3)+(2*5)+(1*1)=149
149 % 10 = 9
So 28783-51-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H11ClO4/c1-3-12-7(10)6(5-9)8(11)13-4-2/h5H,3-4H2,1-2H3
28783-51-9Relevant articles and documents
Free-Radical Carbo-Alkenylation of Olefins: Scope, Limitations and Mechanistic Insights
Beniazza, Redouane,Liautard, Virginie,Poittevin, Clément,Ovadia, Benjamin,Mohammed, Shireen,Robert, Frédéric,Landais, Yannick
supporting information, p. 2439 - 2447 (2017/02/23)
The three-component free-radical carbo-alkenylation of electron-rich olefins has been studied, varying the substitution pattern in the alkene, in the radical precursor and in the final acceptor. New vinylsulfones were also prepared and their reactivity investigated. The scope and limitations of the process was established, and the reaction mechanism clarified using selected dienes as radical clocks. It was thus recognised that the reversible addition onto the olefin of the released sulfonyl group is an important event, which should not be overlooked when using such multicomponent carbo-alkenylation reactions.
Synthesis and lipase-catalyzed asymmetric acetylation of 3-hydroxyl-2-hydroxymethylpropanal acetals
Egri, Gabriella,Fogassy, Elemer,Novak, Lajos,Poppe, Laszlo
, p. 547 - 557 (2007/10/03)
Prochiral dialkylacetal derivatives of 3-hydroxy-2-hydroxymethylpropanal 6a-e were synthesized from the corresponding 2-substituted diethyl malonates 5a-e and subjected to asymmetric enzymatic acetylation. The diethyl malonates 5a-f were prepared from diethyl chloromethylenemalonate 3 by using either a one- or a two-step process. Asymmetric acetylation of 3-hydroxy-2-hydroxymethylpropanal diethyl acetal 6b with several enzymes was studied first, showing the highest enantiotopic selectivity with lipase from Pseudomonas fluorescens (PFL). Solvent effect was also investigated: the best selectivity was obtained in a mixture of hexane and diethyl ether. Furthermore, several other acetals 6a-e were also tested under the optimal acetylation conditions.
