70358-02-0Relevant academic research and scientific papers
Solvent-free microwave Michael addition between EMME and various nucleophiles
Loupy, Andre,Song, Suk Jin,Cho, Seong Jin,Park, Dong Kyu,Kwon, Tae Woo
, p. 79 - 87 (2007/10/03)
Michael addition reaction between EMME and various O, S, N nucleophiles were investigated in the presence of catalysts such as KF, KOH, or K(OCCH 3)3 under solvent-free conditions either neat or on alumina as solid support. Compared
Synthesis and lipase-catalyzed asymmetric acetylation of 3-hydroxyl-2-hydroxymethylpropanal acetals
Egri, Gabriella,Fogassy, Elemer,Novak, Lajos,Poppe, Laszlo
, p. 547 - 557 (2007/10/03)
Prochiral dialkylacetal derivatives of 3-hydroxy-2-hydroxymethylpropanal 6a-e were synthesized from the corresponding 2-substituted diethyl malonates 5a-e and subjected to asymmetric enzymatic acetylation. The diethyl malonates 5a-f were prepared from diethyl chloromethylenemalonate 3 by using either a one- or a two-step process. Asymmetric acetylation of 3-hydroxy-2-hydroxymethylpropanal diethyl acetal 6b with several enzymes was studied first, showing the highest enantiotopic selectivity with lipase from Pseudomonas fluorescens (PFL). Solvent effect was also investigated: the best selectivity was obtained in a mixture of hexane and diethyl ether. Furthermore, several other acetals 6a-e were also tested under the optimal acetylation conditions.
