288-48-2

Usage

Uses

Used in Agricultural Applications:
Thiadiazole is used as an insecticide synergist, cross-linked polymer compound, and herbicide for its effectiveness in enhancing the performance of these products and improving crop protection.
Used in Pharmaceutical Applications:
Thiadiazole is used as a sedative for its calming effects on the central nervous system.
Used in Antibacterial and Antifungal Applications:
Thiadiazole is used as an antibacterial and antifungal agent for its ability to inhibit the growth of harmful microorganisms.
Used in Antiviral Applications:
Thiadiazole is used as an antiviral agent for its potential to inhibit viral replication and reduce the severity of viral infections.
Used in Neurodegenerative Applications:
Thiadiazole is used in the development of treatments for neurodegenerative diseases due to its potential neuroprotective properties.

Chemical Reactivity

As is evident from the electron density map on the ring atoms, both C4 and C5 carbon atoms have the least electron density compared to nitrogen, making them resistant to electrophilic attack on carbon atoms but facile to nitrogen atoms. However, nucleophilic substitution is facile to carbon atoms.

InChI:InChI=1/C2H2N2S/c1-2-5-4-3-1/h1-2H

Upstream product

• 4100-13-4 1,2,3-thiadiazole-4-carboxylic acid 
• 64-04-0 phenethylamine 
• 37566-39-5 5-bromo-2-amino-1,3,4-thiadiazole 

Downstream Products

• 18212-32-3 ethynylsulfanylmethylbenzene 
• 21010-22-0 N,N-diethyl thioacetamide 
• 87576-36-1 Toluene-4-sulfonate3-methyl-[1,2,3]thiadiazol-3-ium; 
• 75-15-0 carbon disulfide 
• 18282-77-4 thioketene 
• 53750-02-0 ethynethiol 
• 157-20-0 ethylene sulphide 
• 930-35-8 1,3-dithiol-2-thione 
• 94843-17-1 4,5-Bis-(4-hydroxyphenyl)-1,2,3-thiadiazole 
• 94843-36-4 4,5-Bis-[4-(N-ethylamino)-phenyl]-1,2,3-thiadiazole 
• 205040-95-5 2-amino-5-[N-(1,3-benzodioxol-5-ylmethyl)amino]-1,3,4-thiadiazole 

Relevant academic research and scientific papers

8-hydroxy-7-substituted quinolines as anti-viral agents

The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula III These compounds are useful as anti-viral agents. Specifically, these compounds have anti-viral activity against the herpes virus, cytomegalovirus (CMV). Many of these compounds are also active against other herpes viruses, such as the varicella zoster virus, the Epstein-Barr virus, the herpes simplex virus and the human herpes virus type 8 (HHV-8).

4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.

Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents

The present invention provides thiadiazolyl and oxadiazolyl phenyl oxzolidinone compounds of formula I STR1 wherein Q is thiadiazolyl or oxadiazolyl; wherein X1 and X2 are independently hydrogen, fluorine or chlorine; and wherein R1 is, for example, --COCH3 or --COCH2 CH3. These compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive and gram-negative aerobic bacteria.

1,3-Dithiol-4,5-dithiolate and 5,6-Dihydro-1,4-diselenin-2,3-dithiolate Nickel Complexes

With the goal of obtaining new ethylenedithiolate transition metals complexes, unstable tetrabutylammonium bis(1,3-dithiol-4,5-dithiolato)niccolate(III) and stable tetrabutylammonium bis(5,6-dihydro-1,4-diselenin-2,3-dithiolato)niccolate(III) were synthesized. The two complexes were characterized by elemental analysis and IR and electron absorption spectroscopy, and the second, also by voltammetry. A new convenient procedure was proposed for preparation of 1,3-dithiol-2-thione which is a key initial compound in the synthesis of the title complexes.

Bis-oxadiazolyl phenyl aromatic diester compounds and their use as ultraviolet stabilizers in organic compositions

The invention relates to bis-oxadiazolyl phenyl aromatic diesters compounds which have been found to be extremely effective ultraviolet stabilizers. The invention also relates to ultraviolet degradable organic compositions containing an amount of a bis-heterocyclic benzoate composition to prevent such degradation. These stabilizers are effective in the presence of other additives commonly employed in polymeric compositions including, for example, pigments, colorants, fillers, reinforcing agents and the like. These ultraviolet stabilizers may also be incorporated into the organic compositions such as polymers by adding to the polymer melt or dissolved in the polymer dope, coated on the exterior of the shaped or molded article, film or extruded fiber.