18212-32-3

Basic information

• Product Name: ethynylsulfanylmethylbenzene
• Synonyms: ethynylsulfanylmethylbenzene
• CAS NO: 18212-32-3
• Molecular Weight: 148.229
• Mol File: 18212-32-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: ethynylsulfanylmethylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: ethynylsulfanylmethylbenzene(18212-32-3)
• EPA Substance Registry System: ethynylsulfanylmethylbenzene(18212-32-3)

Safety Data

• Hazardous Substances Data: 18212-32-3(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 150-60-7 dibenzyl disulphide 
• 540-59-0 1,2-Dichloroethylene 
• 75-35-4 1,1-Dichloroethylene 
• 100-53-8 phenylmethanethiol 
• 1066-54-2 trimethylsilylacetylene 
• 105066-18-0 benzyl trimethylsilylethynyl sulfide 
• 288-48-2 1,2,3-thiadiazole 
• 100-44-7 benzyl chloride 

Downstream Products

• 1253389-89-7 1-(benzylthio)vinyl diphenyl phosphate 
• 937369-88-5 C₁₃H₁₃NO₃S 
• 159497-49-1 (E,Z)-1,4-bis(benzylthio)-1-iodo-6-(trimethylsilyl)hexa-1,3-diene-5-yne 
• 192433-74-2 (Z)-3-benzylthio-2-(2-benzylthiovinyl)benzo[b]thiophene 
• 159497-47-9 (E,E)-1,4-bis(benzylthio)-1,4-diiodo-1,3-butadiene 
• 17284-09-2 (E,E)-2,5-bis(benzylthio)-2,4-hexadiene 
• 79208-53-0 bis(benzylsulfanyl)acetylene 
• 192433-67-3 3-benzylthio-2-benzylthioethynylbenzo[b]thiophene 
• 159497-44-6 1,4-bis(benzylthio)-1,3-butadiyne 

Relevant articles and documents

HETEROARYL PLASMA KALLIKREIN INHIBITORS

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Synthesis of Isothiochroman-3-ones via Metal-Free Oxidative Cyclization of Alkynyl Thioethers

A novel Br?nsted acid-catalyzed oxidative C-H functionalization of alkynyl thioethers has been developed. This method allows the practical synthesis of valuable isothiochroman-3-ones in mostly moderate to good yields under mild reaction conditions and features a broad substrate scope and wide functional group tolerance. Moreover, this metal-free oxidation can also be used to promote formal N-H insertion involving an unexpected 1,2-sulfur migration, affording useful 1,4-benzothiazin-3-ones.

Divergent Reactivity of Thioalkynes in Lewis Acid Catalyzed Annulations with Donor–Acceptor Cyclopropanes

Efficient methods for the convergent synthesis of (poly)cyclic scaffolds are urgently needed in synthetic and medicinal chemistry. Herein, we describe new annulation reactions of thioalkynes with phthalimide-substituted donor–acceptor cyclopropanes, which gave access to highly substituted cyclopentenes and polycyclic ring systems. With silyl-thioalkynes, the Lewis acid catalyzed [3+2] annulation reaction with donor–acceptor cyclopropanes took place to afford 1-thio-cyclopenten-3-amines. On the other hand, an unprecedented polycyclic compound was formed with alkyl-thioalkynes through a reaction pathway directly involving the phthalimide group. The two transformations proceeded in good yields and tolerated a large variety of functional groups.