2880-06-0

Basic information

• Product Name: (R)-(+)-methyl 3-phenylpentanoate
• Synonyms: (R)-(+)-methyl 3-phenylpentanoate
• CAS NO: 2880-06-0
• Molecular Weight: 192.258
• Mol File: 2880-06-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (R)-(+)-methyl 3-phenylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-methyl 3-phenylpentanoate(2880-06-0)
• EPA Substance Registry System: (R)-(+)-methyl 3-phenylpentanoate(2880-06-0)

Safety Data

• Hazardous Substances Data: 2880-06-0(Hazardous Substances Data)

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 103-26-4 methyl cinnamate 
• 221044-26-4 (4S)-4-phenyl-3-<(3R)-3-phenylpentanoyl>-1,3-oxazolidin-2-one 
• 159652-02-5 (R)-3-phenylvaleryl chloride 
• 100-58-3 phenylmagnesium bromide 
• 5669-17-0 (R) 3-phenylvaleric acid 
• 2845-27-4 3-phenylpentanoic acid 
• 67478-54-0 ethyl 3-ethyl-3-phenylpropionate 
• 60066-61-7 ethyl 3-phenyl-4-pentenoate 
• 104-54-1 3-Phenylpropenol 
• 79164-26-4 C₁₅H₂₁NO₂ 
• 84009-51-8 methyl (E)-3-phenyl-2-pentenoate 
• 19713-73-6 methyl (2Z)-3-phenylprop-2-enoate 
• 15790-87-1 Methyl (E)-2-pentenoate 

Downstream Products

• 159563-71-0 3-([S]-α-ethylbenzyl)-4-hydroxy-6-([R]-α-ethylphenethyl)-2H-pyran-2-one 

Relevant articles and documents

Chiral Ugi-type amines: Practical synthesis, ligand development, and asymmetric catalysis

Ugi's amine has become one type of privileged chiral skeleton for chiral ligand design bearing central/planar chirality, and such ligands have exhibited tremendous success in various asymmetric catalysis. However, the current access to enantiopure Ugi's amine is quite tedious and relies heavily on optical resolution, which impedes its practical applications, to some extent. Herein, we present a facile asymmetric synthesis of enantioenriched Ugi-type amines bearing a long-carbon chain through Ir-catalyzed cascade allylation/2-aza-Cope rearrangement, followed by amino exchange and Pd/C-catalyzed one-pot hydrogenation/reductive amination. The protocol could be readily scaled up, and it has been conducted in 20-g-scale asymmetric synthesis of (S)-Ugi-type amine from commercially available reagents, in >99% ee and >70% overall yield in four steps with one short silica gel-plug purification. (S,Rp)-PPFA-type and (S,Rp)-Josiphos-type ligands, readily prepared from the achieved Ugi-type amine, exhibited higher or comparable asymmetric induction and catalytic efficacy in several Cu(I)-catalyzed asymmetric reactions, which indicated great potential of the applications of the readily accessible Ugi-type amines in ligand/catalyst design.

Asymmetric NaBH4 1,4-reduction of C3-disubstituted 2-propenoates catalyzed by a diamidine cobalt complex

A new Co complex of a unique diamidine ligand catalyzes asymmetric NaBH4 reduction of C3-disubstituted (E)- and (Z)-2-propenoates, including C3-oxygen- and nitrogen-substituted substrates with high enantioselectivity. Analysis by X-ray diffract

Chiral boronate derivatives via catalytic enantioselective conjugate addition of grignard reagents on 3-boronyl unsaturated esters and thioesters

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