60066-61-7

Basic information

• Product Name: Benzenepropanoic acid, b-ethenyl-, ethyl ester
• CAS NO: 60066-61-7
• Molecular Formula: C13H16O2
• Molecular Weight: 204.269
• Mol File: 60066-61-7.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, b-ethenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-ethenyl-, ethyl ester(60066-61-7)
• EPA Substance Registry System: Benzenepropanoic acid, b-ethenyl-, ethyl ester(60066-61-7)

Safety Data

• Hazardous Substances Data: 60066-61-7(Hazardous Substances Data)

Upstream product

• 78-39-7 Triethyl orthoacetate 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 2678-54-8 ketene diethyl acetal 
• 122-51-0 orthoformic acid triethyl ester 
• 104-54-1 3-Phenylpropenol 
• 64-17-5 ethanol 
• 137586-02-8 3-Phenyl-pent-4-enoyl chloride 
• 5703-57-1 3-phenylpent-4-enoic acid 
• 4510-34-3 (Z)-cinnamyl alcohol 
• 21040-45-9 Cinnamyl acetate 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 

Downstream Products

• 1026680-48-7 N-benzyl-3-phenyl-4-pentenamide 
• 60066-58-2 ethyl 2-methyl-3-phenyl-4-pentenoate 
• 1311201-63-4 (R)-(+)-3-phenyl-4-pentenoic acid ethyl ester 
• 209900-64-1 (S)-3-phenyl-4-pentenoic acid 
• 5669-17-0 (R) 3-phenylvaleric acid 
• 52950-37-5 4-amino-(3S)-3-phenyl-butyric acid hydrochloride 

Relevant articles and documents

Total Synthesis of (-)-Isoschizogamine

The total synthesis of (-)-isoschizogamine was accomplished, featuring the construction of the quaternary carbon center by the modified Johnson-Claisen rearrangement in basic media and the facile assembly of the key tetracyclic quinolone intermediate through a cascade cyclization. The characteristic cyclic aminal was constructed by late-stage C-H functionalization at the position adjacent to the lactam nitrogen using a combination of CrO3 and nBu4NIO4 and subsequent Bi(OTf)3-mediated cyclization.

Atmospheric Oxygen Mediated Radical Hydrothiolation of Alkenes

A mild, metal-free, atmospheric oxygen-mediated radical hydrothiolation of alkenes (and alkyne) is reported. A variety of sulfur containing motifs including alkanethiols, thiophenols and thioacids undergo an atmospheric oxygen-mediated radical hydrothiolation reaction with a plethora of alkenes in good yield with excellent functional group compatibility, typically with short reaction times to furnish a range of functionalized products. Biomolecules proved tolerant to the conditions and the procedure is robust and easily executable requiring no specialized equipment. Concise mechanistic studies confirm the process proceeds through radical intermediates in a thiol-ene reaction manifold. The methodology offers an efficient “green” approach for thiol-ene mediated “click” ligation and a milder alternative to thermally initiated hydrothiolation processes.

Synthesis of 5-[(Pentafluorosulfanyl)methyl]-γ-butyrolactones via a Silver-Promoted Intramolecular Cyclization Reaction

The synthesis of 5-[(pentafluorosulfanyl)methyl]-γ-butyrolactones bearing different substituents at position 3 or 4 is reported. A silver-promoted intramolecular cyclization of substituted 4-chloro-5-(pentafluorosulfanyl)pentanoic acids allows the preparation of the substituted SF5-containing γ-butyrolactones in up to 96 % yield.