288083-60-3Relevant articles and documents
Identification of critical process impurities and their impact on process research and development
Huang, Yande,Ye, Qingmei,Guo, Zhenrong,Palaniswamy, Venkatapuram A.,Grosso, John A.
, p. 632 - 636 (2008)
The identification of low-level critical process impurities and degradants encountered during pharmaceutical development is crucial to the process development, but can often be challenging and can negatively impact the timeline of the developmental program. This is demonstrated during the early stage of process research and development of a Factor Xa inhibitor, the caprolactam 1. Details focusing on rapid identification of impurities in the active pharmaceutical ingredient (API), recognition of their root causes of formation, and the impact on process development are described.
INHIBITORS OF HISTONE DEACETYLASE
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Page/Page column 68-69, (2010/02/14)
The invention relates to a series of compounds useful for inhibiting histone deacetylase (HDAC) enzymatic activity. The invention also provides a method for inhibiting histone descetylase in a cell using said compounds as well as a method for treating cell proliferative diseases and conditions using said HDAC inhibitors. Further, the invention provides pharmaceutical compositions comprising the HDAC inhibiting compounds and a pharmaceutically acceptable carrier.