288087-80-9

Basic information

• Product Name: (Z)-3-Amino-4,4,4-trichloro-1-(2-hydroxy-5-methyl-phenyl)-but-2-en-1-one
• Synonyms: (Z)-3-Amino-4,4,4-trichloro-1-(2-hydroxy-5-methyl-phenyl)-but-2-en-1-one
• CAS NO: 288087-80-9
• Molecular Weight: 294.565
• Mol File: 288087-80-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-3-Amino-4,4,4-trichloro-1-(2-hydroxy-5-methyl-phenyl)-but-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-Amino-4,4,4-trichloro-1-(2-hydroxy-5-methyl-phenyl)-but-2-en-1-one(288087-80-9)
• EPA Substance Registry System: (Z)-3-Amino-4,4,4-trichloro-1-(2-hydroxy-5-methyl-phenyl)-but-2-en-1-one(288087-80-9)

Safety Data

• Hazardous Substances Data: 288087-80-9(Hazardous Substances Data)

Upstream product

• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 545-06-2 trichloroacetonitrile 

Downstream Products

• 13252-83-0 4-hydroxy-6-methylcoumarin 
• 152894-72-9 2-trichloromethyl-6-methylchromone 

Relevant articles and documents

Condensation of 2-hydroxyacetophenones with trichloroacetonitrile as a route to 2-trichloromethylchromones and 4-hydroxycoumarins

Condensation of 2-hydroxyacetophenones with trichloroacetonitrile in the presence of N-methylanilinomagnesium bromide affords hydroxyaryl β-amino-β-trichloromethylvinyl ketones, which are converted into 2-trichloromethylchromones upon treatment with concentrated HCl. The resulting compounds react with alcoholic solutions of NH3 or KOH to form 3-amino-1-(2-hydroxyaryl)-4,4,4-trichlorobut-2-en-1-ones and 4-hydroxycoumarins, respectively.