152894-72-9

Upstream product

• 16108-51-3 2,6-dimethyl-chromen-4-one 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 288087-80-9 (Z)-3-Amino-4,4,4-trichloro-1-(2-hydroxy-5-methyl-phenyl)-but-2-en-1-one 

Downstream Products

• 13252-83-0 4-hydroxy-6-methylcoumarin 

Relevant academic research and scientific papers

Condensation of 2-hydroxyacetophenones with trichloroacetonitrile as a route to 2-trichloromethylchromones and 4-hydroxycoumarins

Condensation of 2-hydroxyacetophenones with trichloroacetonitrile in the presence of N-methylanilinomagnesium bromide affords hydroxyaryl β-amino-β-trichloromethylvinyl ketones, which are converted into 2-trichloromethylchromones upon treatment with concentrated HCl. The resulting compounds react with alcoholic solutions of NH3 or KOH to form 3-amino-1-(2-hydroxyaryl)-4,4,4-trichlorobut-2-en-1-ones and 4-hydroxycoumarins, respectively.

REACTIONS WITH 2-METHYLCHROMONES

The reactivity of 2-methylchromones and their derivatives towards nucleophilic and electrophilic reagents, cycloaddition reactions, thiation, reactions with compounds containing active methylene group has been investigated.The IR, 1H-NMR and mass spectra of new chromone derivatives were discussed.Key words: 2-Methylchromones, cycloaddition reactions with compounds containing active methylene