288102-94-3

Upstream product

• 57-13-6 urea 
• 349148-14-7 2-methyl-2-(4-phenoxy-phenyl)-malonic acid dimethyl ester 
• 288103-00-4 dimethyl 2-(4-phenoxyphenyl)malonate 
• 4664-61-3 methyl [p-(phenoxy)phenyl]acetate 

Relevant academic research and scientific papers

Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors

The 5,5-disubstitutedpyrimidine-2,4,6-triones represent a new class of MMP inhibitors showing selectivity for the gelatinases A and B, collagenase-3, and human neutrophil collagenase. The SAR presented here is in good agreement with an X-ray structure of compound 5 bound to the catalytic domain of stromelysin-1. While of the barbiturate structural class, compound 5 did not show any toxic or sedative effects.