349148-14-7Relevant academic research and scientific papers
Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors
Foley, Louise H,Palermo, Robert,Dunten, Pete,Wang, Ping
, p. 969 - 972 (2007/10/03)
The 5,5-disubstitutedpyrimidine-2,4,6-triones represent a new class of MMP inhibitors showing selectivity for the gelatinases A and B, collagenase-3, and human neutrophil collagenase. The SAR presented here is in good agreement with an X-ray structure of compound 5 bound to the catalytic domain of stromelysin-1. While of the barbiturate structural class, compound 5 did not show any toxic or sedative effects.
