28814-66-6Relevant academic research and scientific papers
First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents
Lee, Chia-Lin,Huang, Chi-Huan,Wang, Hui-Chun,Chuang, Da-Wei,Wu, Ming-Jung,Wang, Sheng-Yang,Hwang, Tsong-Long,Wu, Chin-Chung,Chen, Yeh-Long,Chang, Fang-Rong,Wu, Yang-Chang
supporting information; experimental part, p. 70 - 73 (2011/02/23)
Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total syn
DNA cleavage by Di- and trihydroxyalkylbenzenes. Characterization of products and the roles of O2, Cu(II), and alkali
Singh, Udai S.,Scannell, Ralph T.,An, Haoyun,Carter, Barbara J.,Hecht, Sidney M.
, p. 12691 - 12699 (2007/10/03)
Several 5-alkyl-1,3-dihydroxybenzene (5-alkylresorcinol, 1) and 6-alkyl-1,2,4-trihydroxybenzene (2) derivatives were prepared and used to study the mechanism by which such compounds effect Cu(II)-dependent DNA strand scission. Comparison of the methyl, n-pentyl, n-undecyl, and n-hexadecyl derivatives in each structural series indicated that the efficiency of DNA cleavage increased with increasing length of the alkyl substituent. DNA cleavage by the 5-alkylresorcinols appears to involve initial oxygenation of the benzene nucleus, a process that occurs readily at alkaline pH in the presence of Cu2+ and O2. The resulting trihydroxylated benzenes mediate DNA cleavage in a reaction dependent on the presence of both Cu2+ and O2. The mechanism appears to involve reduction of Cu2+ by the trihydroxybenzene moiety in 2, with subsequent formation of reactive oxygen species. The ability of catalase and dimethyl sulfoxide to suppress DNA strand scission is consistent with the intermediacy of H2O2 and ?OH in the DNA strand scission process.
The Reactions of Lignin with Alkaline Hydrogen Peroxide. Part IV. Products from the Oxidation of Quinone Model Compounds
Gellerstedt, Goeran,Hardell, Hanne-Lise,Lindfors, Eva-Lisa
, p. 669 - 674 (2007/10/02)
Simple para- and orhto-quinoid structures related to lignin have been oxidized with hydrogen peroxide under mild alkaline conditions.Most of the reaction products, i.e. carboxylic acids formed by oxidative cleavage of the quinoid ring together with acids formed by more extensive degradation of the starting materials, were identified after conversion into esters.In addition, small amounts of hydroxylated quinones were found.Mechanisms for the formation of these products are suggested and the significance of the results for the bleaching of mechanical pulps with hydrogen peroxide is briefly discussed.
