288145-03-9

Upstream product

• 20989-17-7 (2S)-2-phenylglycinol 
• 100-52-7 benzaldehyde 
• 56613-80-0 D-2-phenylglycinol 

Downstream Products

• 288145-11-9 [2S,2(1R)]-2-phenyl-2-[[1-phenyl-2-(trimethylsilanyl)buta-2,3-dienyl]amino]ethanol 
• 288145-04-0 [2S,2(1S,3E)]-2-phenyl-2-[[1-phenyl-4-(trimethylsilanyl)but-3-enyl]amino]ethanol 
• 288145-07-3 [2S,2(1S)]-2-phenyl-2-[[1-phenyl-4-(trimethylsilanyl)but-3-ynyl]amino]ethanol 

Relevant academic research and scientific papers

Highly diastereoselective N-nitrosation of chiral (E)-2-(benzylidene-amino)ethanols with nitric oxide

N-Nitrosation of (E)-(S)-2-(benzylidene-amino)ethanols 2 with nitric oxide occurred highly diastereoselectively, to give the (2S,4S)-diastereomer dominant N-nitroso-(2S,4S)-1,3-oxazolidines in good yield. Intermediate 2 was prepared from the reaction of b

Chiral phosphinyl analogues of 2-C-arylmorpholinols: 2-aryl-3,5-diphenyl-[1,4,2]-oxazaphosphinanes

(2R,3R,5R)-2-Aryl-3,5-diphenyl-[1,4,2]-oxazaphosphinanes 6, analogues of C-arylmorpholinol 3, were prepared with diastereomeric excess higher than 94%, via a three step sequence: (i) diastereoselective addition-cyclization reaction from methyl hypophosphi

Asymmetric syntheses of new functionalized β-amino alcohols via diastereoselective addition of organometallic reagents onto oxazolidines

Diastereoselective reactions between (S)-phenylglycinol-derived oxazolidines and two unsaturated organolithium reagents afforded chiral β-amino alcohols having vinyl and alkynylsilane moieties. When the same reactions were performed in the presence of titanium isopropoxide, a dramatic change of regioselectivity was observed, from the α- to the γ-position, thus producing β-amino alcohols with allyl or allenylsilane functions. A rationalization of the observed diastereoselectivity was suggested for each case.

Dramatic change of regioselectivity in the addition of silylated organolithium reagents with oxazolidines induced by the presence of a titanium salt

Diastereoselective reactions between oxazolidines and organolithium reagents afford β-amino alcohols having chiral vinyl and alkynylsilane moieties. A meaningful change of regioselectivity, from the α- to the γ-position, occurred when these reactions were

A stereoselective concise synthesis of C2- and meso-aminodiols from (R)-phenylglycinol

Oxazolidines derived from (R)-phenylglycinol can undergo diastereoselective vinyl- and aryl addition to give, after oxidative cleavage, meso- and C2-diethanol amines.