288145-04-0

Basic information

• Product Name: [2S,2(1S,3E)]-2-phenyl-2-[[1-phenyl-4-(trimethylsilanyl)but-3-enyl]amino]ethanol
• Synonyms: [2S,2(1S,3E)]-2-phenyl-2-[[1-phenyl-4-(trimethylsilanyl)but-3-enyl]amino]ethanol
• CAS NO: 288145-04-0
• Molecular Weight: 339.553
• Mol File: 288145-04-0.mol

Chemical Properties

• CAS DataBase Reference: [2S,2(1S,3E)]-2-phenyl-2-[[1-phenyl-4-(trimethylsilanyl)but-3-enyl]amino]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: [2S,2(1S,3E)]-2-phenyl-2-[[1-phenyl-4-(trimethylsilanyl)but-3-enyl]amino]ethanol(288145-04-0)
• EPA Substance Registry System: [2S,2(1S,3E)]-2-phenyl-2-[[1-phenyl-4-(trimethylsilanyl)but-3-enyl]amino]ethanol(288145-04-0)

Safety Data

• Hazardous Substances Data: 288145-04-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 20989-17-7 (2S)-2-phenylglycinol 
• 288145-03-9 (S)-2,4-Diphenyl-oxazolidine 
• 762-72-1 allyl-trimethyl-silane 

Downstream Products

• 426827-16-9 [4(1S),5S]-5-phenyl-4-(1-phenyl-4-trimethylsilanylbut-3-enyl)morpholin-2-one 

Relevant articles and documents

Asymmetric syntheses of new functionalized β-amino alcohols via diastereoselective addition of organometallic reagents onto oxazolidines

Diastereoselective reactions between (S)-phenylglycinol-derived oxazolidines and two unsaturated organolithium reagents afforded chiral β-amino alcohols having vinyl and alkynylsilane moieties. When the same reactions were performed in the presence of titanium isopropoxide, a dramatic change of regioselectivity was observed, from the α- to the γ-position, thus producing β-amino alcohols with allyl or allenylsilane functions. A rationalization of the observed diastereoselectivity was suggested for each case.

Dramatic change of regioselectivity in the addition of silylated organolithium reagents with oxazolidines induced by the presence of a titanium salt

Diastereoselective reactions between oxazolidines and organolithium reagents afford β-amino alcohols having chiral vinyl and alkynylsilane moieties. A meaningful change of regioselectivity, from the α- to the γ-position, occurred when these reactions were