288153-44-6Relevant academic research and scientific papers
Synthesis of metabolically blocked paclitaxel analogues
Wittman, Mark D.,Altstadt, Thomas J.,Fairchild, Craig,Hansel, Stephen,Johnston, Kathy,Kadow, John F.,Long, Byron H.,Rose, William C.,Vyas, Dolatrai M.,Wu, Mu-Jen,Zoeckler, Mary E.
, p. 809 - 810 (2007/10/03)
The stereospecific syntheses of the metabolically blocked 6-α-F, Cl, Br paclitaxel, and 6-α-F-10-acetyldocetaxel are described and in vitro and in vivo activity is presented.
Stereospecific synthesis of the major human metabolite of paclitaxel
Wittman, Mark D.,Kadow, John F.,Vyas, Dolatrai M.
, p. 4729 - 4731 (2007/10/03)
The stereospecific synthesis of 6-α-hydroxy paclitaxel 10, the major human metabolite of paclitaxel, is described. The 6,7-α-diol 4, obtained from paclitaxel, is converted to the 6,7-β-cyclic sulfate followed by nitrate addition and reduction to afford the title compound. (C) 2000 Elsevier Science Ltd.
