288161-84-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 288161-83-1 N-(1-butyl-1-hydroxymethyl-pentyl)-4-dimethylamino-benzenesulfonamide 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 288161-81-9 di-n-butyl-ethanolamine 
• 288161-82-0 N-(1-butyl-1-hydroxymethyl-pentyl)-4-fluoro-benzenesulfonamide 

Downstream Products

• 288161-85-3 N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-N-methyl-benzenesulfonamide 
• 635752-67-9 N-benzyl-N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-2-(3-ethylamino-benzyl)-benzenesulfonamide 
• 288161-93-3 N-benzyl-N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-2-(3-nitro-benzyl)-benzenesulfonamide 
• 635752-85-1 2-(3-amino-benzyl)-N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-benzenesulfonamide 
• 288161-87-5 N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-N-methyl-2-(3-nitro-benzyl)-benzenesulfonamide 
• 288161-91-1 N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-2-(3-nitro-benzyl)-benzenesulfonamide 
• 635752-68-0 2-(3-amino-benzyl)-N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-N-methyl-benzenesulfonamide 
• 635752-98-6 N-benzyl-N-(1-butyl-1-formyl-pentyl)-4-dimethylamino-2-(3-ethylamino-benzyl)-benzenesulfonamide 
• 635752-88-4 N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-2-(4-hydroxy-benzyl)-benzenesulfonamide 
• 635752-69-1 N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-2-(3-methoxy-benzyl)-N-methyl-benzenesulfonamide 
• 635752-87-3 N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-2-(4-methoxy-benzyl)-benzenesulfonamide 
• 635752-70-4 N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-2-(4-hydroxy-benzyl)-N-methyl-benzenesulfonamide 
• 288161-90-0 N-[1-butyl-1-(tert-butyl-dimethyl-silanyloxymethyl)-pentyl]-4-dimethylamino-2-(4-methoxy-benzyl)-N-methyl-benzenesulfonamide 
• 288162-02-7 N-benzyl-N-(1-butyl-1-formyl-pentyl)-4-dimethylamino-2-(3-nitro-benzyl)-benzenesulfonamide 

Relevant academic research and scientific papers

A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 1,2-benzothiazepines

A series of 5-aryl-3,3-dibutyl-7-(dimethylamino)-1,2-benzothiazepin-4-ol 1,1-dioxides were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT) for the potential treatment for hyperlipidemia. Several 1,2-benzothiazepines exhibited low nanomolar in vitro activity. The synthesis and initial in vitro potency data is presented for this novel class of compounds.