2882-16-8

Usage

Uses

Used in Organic Synthesis:
3-Phenyl-pyrazine-2-carbonitrile is used as a reactant in the silver-catalyzed Minisci reactions, which are a class of reactions that involve the formation of carbon-heteroatom bonds through the activation of aromatic compounds by a radical mechanism. The use of Selectfluor as a mild oxidant in these reactions allows for the efficient and selective formation of desired products, making 3-Phenyl-pyrazine-2-carbonitrile a valuable intermediate in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
3-Phenyl-pyrazine-2-carbonitrile is also utilized in the development of pharmaceutical compounds, as its unique structure and reactivity can be harnessed to create novel drug candidates with potential therapeutic applications. 3-Phenyl-pyrazine-2-carbonitrile's ability to participate in various chemical reactions makes it a versatile building block for the design and synthesis of new pharmaceutical agents.
Used in Agrochemical Industry:
In addition to its applications in organic synthesis and pharmaceuticals, 3-Phenyl-pyrazine-2-carbonitrile is also employed in the agrochemical industry. Its reactivity and structural features can be leveraged to develop new agrochemical products, such as pesticides and herbicides, that can help improve crop protection and yield.
Overall, 3-Phenyl-pyrazine-2-carbonitrile is a versatile and valuable compound with a wide range of applications across different industries, including organic synthesis, pharmaceuticals, and agrochemicals. Its unique chemical properties and reactivity make it an essential component in the development of new and innovative products.

Upstream product

• 2882-17-9 2-bromo-3-phenylpyrazine 
• 603-33-8 triphenylbismuthane 
• 55557-52-3 2-chloro-3-cyanopyrazine 
• 19847-12-2 2-pyrazine carbonitrile 
• 98-80-6 phenylboronic acid 
• 7677-24-9 trimethylsilyl cyanide 
• 29460-97-7 2-phenylpyrazine 
• 2882-18-0 3-phenyl-2(1H)-pyrazinone 

Relevant academic research and scientific papers

C?H Cyanation of 6-Ring N-Containing Heteroaromatics

Heteroaromatic nitriles are important compounds in drug discovery, both for their prevalence in the clinic and due to the diverse range of transformations they can undergo. As such, efficient and reliable methods to access them have the potential for far-reaching impact across synthetic chemistry and the biomedical sciences. Herein, we report an approach to heteroaromatic C?H cyanation through triflic anhydride activation, nucleophilic addition of cyanide, followed by elimination of trifluoromethanesulfinate to regenerate the cyanated heteroaromatic ring. This one-pot protocol is simple to perform, is applicable to a broad range of decorated 6-ring N-containing heterocycles, and has been shown to be suitable for late-stage functionalization of complex drug-like architectures.

Silver-Catalyzed Minisci Reactions Using Selectfluor as a Mild Oxidant

A new method for silver-catalyzed Minisci reactions using Selectfluor as a mild oxidant is reported. Heteroarenes and quinones both participate in radical C-H alkylation and arylation from a variety of carboxylic and boronic acid radical precursors. Several oxidatively sensitive and highly reactive radical species are successful, providing structures that are challenging to access by other means.

Scope and limitation for FeSO4-mediated direct arylation of heteroarenes with arylboronic acids and its synthetic applications

FeSO4-mediated direct arylation of heteroarenes with arylboronic acids in the presence of K2S2O8 has been developed. A slow addition of an aqueous solution of an iron complex was crucial in the arylation. Scope and limitation of the heteroarenes and arylboronic acids are discussed. Furthermore, the direct arylation was applied to the formal total synthesis botryllazine B and sodium channel inhibitor.

Palladium-catalyzed cross-coupling reaction of functionalized aryl- and heteroarylbismuthanes with 2-halo(or 2-Triflyl)azines and -diazines

The palladium-catalyzed cross-coupling of highly functionalized organobismuthanes with 2-halo(or 2-triflyl)pyridines, -pyrimidines, -pyrazines, and -pyridazines is reported. The reaction tolerates numerous functional groups, including aldehydes. The synthesis of a shelf-stable (formylphenyl)bismuth reagent and its use in a cross-coupling reaction is also described. The palladium-catalyzed cross-coupling of highly functionalized organobismuthanes with 2-halo(or 2-triflyl)pyridines, -pyrimidines, -pyrazines, and -pyridazines is reported. The reaction tolerates numerous functional groups, including aldehydes. The synthesis of a shelf-stable (formylphenyl)bismuth reagent and its use in cross-coupling reactions is also described. Copyright