288251-72-9Relevant articles and documents
Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2 H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors
Li, Zizhou,Xiao, Senhao,Yang, Yaxi,Chen, Chao,Lu, Tian,Chen, Zhifeng,Jiang, Hualiang,Chen, Shijie,Luo, Cheng,Zhou, Bing
, p. 3956 - 3975 (2020/05/27)
The bromodomain and extra-terminal (BET) family proteins have recently emerged as promising drug targets for cancer therapy. In this study, identification of an 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one fragment (47) as a new binder to the BET bromodomains