14225-16-2

Basic information

• Product Name: Benzene, 1-(2,2-dimethylpropoxy)-4-nitro-
• CAS NO: 14225-16-2
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.245
• Mol File: 14225-16-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2,2-dimethylpropoxy)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2,2-dimethylpropoxy)-4-nitro-(14225-16-2)
• EPA Substance Registry System: Benzene, 1-(2,2-dimethylpropoxy)-4-nitro-(14225-16-2)

Safety Data

• Hazardous Substances Data: 14225-16-2(Hazardous Substances Data)

Upstream product

• 75-84-3 2,2-dimethyl-propanol-1 
• 100-00-5 4-chlorobenzonitrile 
• 350-46-9 4-Fluoronitrobenzene 
• 100-02-7 4-nitro-phenol 
• 100-17-4 para-methoxynitrobenzene 
• 210693-58-6 [(R)-Tol-BINAP]Pd(p-C₆H₄NO₂)(OCH₂CMe₃) 
• 210693-64-4 (dppf)Pd(p-C₆H₄NO₂)(OCH₂CMe₃) 
• 108-95-2 phenol 
• 2189-88-0 1-phenoxy-2,2-dimethylpropane 

Downstream Products

• 288251-71-8 3-bromo-4-neopentyloxyaniline 
• 288249-53-6 N-(3-bromo-4-neopentyloxyphenyl)-1-(4-fluorophenyl)-3-methylpyrazole-4-carboxamide 
• 288251-72-9 3-bromo-4-neopentyloxynitrobenzene 
• 85258-83-9 5-[4-(2,2-Dimethyl-propoxy)-phenyl]-thiazolidine-2,4-dione 
• 85259-07-0 (E)-3-[4-(2,2-Dimethyl-propoxy)-phenyl]-acrylic acid 
• 210694-04-5 4-(2,2-dimethylpropoxy)benzaldehyde 
• 62517-04-8 ethyl 2-chloro-3-[4-(2,2-dimethylpropyloxy)phenyl]-propionate 
• 62517-38-8 4-(2,2-dimethyl-propoxy)-phenylamine 
• 62517-07-1 2-Chloro-3-[4-(2,2-dimethyl-propoxy)-phenyl]-propionamide 

Relevant articles and documents

Phosphazene Base tBu-P4 Catalyzed Methoxy–Alkoxy Exchange Reaction on (Hetero)Arenes

The organic superbase tBu-P4 catalyzes methoxy-alkoxy exchange reactions on (hetero)arenes with alcohols. The catalytic reaction proceeded efficiently with electron-deficient methoxy(hetero)arenes as well as with a variety of alcohols, including 3-amino-1-propanol, β-citronellol, menthol, and cholesterol. An intramolecular version of this reaction furnished six- and seven-membered ring compounds.

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.