288251-79-6

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 16588-15-1 2-chloro-5-nitro-benzamide 

Downstream Products

• 288251-78-5 5-amino-2-(4-hydroxypiperidin-1-yl)benzonitrile 
• 288251-22-9 1-(4-chlorophenyl)-N-{3-cyano-4-[4-(2-hydroxypiperidin-1-yl)piperidin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide 
• 288251-38-7 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-oxopiperidin-1-yl)piperidin-1-yl]phenyl]-5-methylpyrazole-4-carboxamide 
• 288250-39-5 1-{4-[1-(4-chlorophenyl)-5-methylpyrazole-4-carboxamide]-2-cyanophenyl}-4-piperidinylbenzoate 
• 288250-02-2 N-(3-cyano-4-(4-tert-butyldimethylsilyloxypiperidin-1-yl)phenyl)-1-(4-fluorophenyl)-3-methylpyrazole-4-carboxamide 
• 288249-88-7 N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-5-methylpyrazol-4-ylcarbonyl]glycine 
• 288250-03-3 N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-3-methylpyrazol-4-ylcarbonyl]glycine 
• 288249-36-5 4-(1-[2-cyano-4-(1,5-dimethyl-4-pyrazolecarboxamide)phenyl]piperidine-4-yloxy)-4-oxobutyric acid 
• 288249-85-4 N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-1-(4-fluorophenyl)-3-methylpyrazole-4-carboxamide 
• 288249-76-3 N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-40-8 1-(4-chlorophenyl)-N-[3-cyano-4-(hydroxypiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide 
• 288251-20-7 N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-5-methyl-1-phenylpyrazole-4-carboxamide 
• 288249-86-5 N-(3-cyano-4-(4-tert-butyldimethylsilyloxypiperidin-1-yl)phenyl)-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288252-15-3 1-(2-cyano-4-nitrophenyl)-4-piperidinyl benzoate 

Relevant academic research and scientific papers

PROTEIN KINASE C INHIBITORS AND USES THEREOF

This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to ph

THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY

To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R 1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R 2 is methyl; R 3 is a hydrogen atom; and R 4 is a group: -CONR 5 R 6 (in which any one of R 5 and R 6 is a hydrogen atom)].

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.