288251-81-0

Basic information

• Product Name: 2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-nitrobenzonitrile
• Synonyms: 2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-nitrobenzonitrile
• CAS NO: 288251-81-0
• Molecular Formula: C13H16N4O3
• Molecular Weight: 276.29114
• Mol File: 288251-81-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-nitrobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-nitrobenzonitrile(288251-81-0)
• EPA Substance Registry System: 2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-nitrobenzonitrile(288251-81-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 288251-81-0(Hazardous Substances Data)

Usage

Properties

Contains a piperazine ring, a nitro group, and a nitrile group

Molecular weight

281.29 g/mol

Potential applications

Pharmaceutical industry as a building block for drug synthesis

Biological activity

Research ongoing into potential medicinal properties

Safety precautions

Proper handling and safety measures should be observed when working with the compound

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 16588-15-1 2-chloro-5-nitro-benzamide 
• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 

Downstream Products

• 288250-20-4 1-(2-chloro-5-trifluoromethylphenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide 
• 288250-69-1 N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-1-(4-trifluoromethylphenyl)-5-methylpyrazole-4-carboxamide 
• 288250-61-3 N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-1-(3,4-difluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-58-8 2-(4-{4-[1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxamide]-2-cyanophenyl}piperazin-1-yl) ethyl acetate 
• 288250-11-3 N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-1-(4-fluorophenyl)-3,5-dimethylpyrazole-4-carboxamide 
• 288250-46-4 1-(3,4-dichlorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide 
• 288250-63-5 1-(3-chloro-4-fluorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide 
• 288249-95-6 N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-1-(2,4-difluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-29-3 N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-1-(4-iodophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-25-9 N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-1-(4-methoxyphenyl)-5-methylpyrazole-4-carboxamide 
• 288250-28-2 1-(4-bromophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide 
• 288250-23-7 1-(4-chlorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide 
• 288250-45-3 1-(3-chlorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide 
• 288250-44-2 1-(4-chlorophenyl)-N-{3-cyano-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}pyrrole-3-carboxamide 

Relevant articles and documents

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.