288251-85-4

Usage

Uses

Used in Medicinal Chemistry:
Tert-Butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate is used as a structural fragment for lead optimization in the development of pharmaceuticals with central nervous system activity. Its unique chemical structure, including the carboxylate ester and the presence of amino and cyano groups, makes it a promising candidate for further research and development in this field.
Used in Drug Discovery:
In the pharmaceutical industry, Tert-Butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate is utilized as a potential lead compound for the discovery of new drugs. Its versatile chemical properties and potential biological activities, such as receptor binding or enzyme inhibition, make it a valuable tool in the search for novel therapeutic agents.
Used in CNS-active Pharmaceutical Development:
Tert-Butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate is employed as a key component in the development of pharmaceuticals targeting the central nervous system. Its potential to interact with receptors or inhibit enzymes within the CNS makes it a valuable asset in the creation of new treatments for neurological disorders and conditions.

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 
• 288251-86-5 5-nitro-2-(piperazin-1-yl)benzonitrile 
• 16588-15-1 2-chloro-5-nitro-benzamide 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 17417-09-3 2-fluoro-5-nitrobenzonitrile 
• 288251-87-6 tert-butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate 

Downstream Products

• 288250-36-2 tert-butyl 4-{4-[1-(4chlorophenyl)-5-methyl-4-pyrazolecarboxamide]-cyanophenyl}piperazin-1-ylcarboxylate 
• 288250-14-6 tert-butyl N-{2-cyano-4-[1-(4-fluorophenyl)-5-methyl-4-pyrazolecarboxamide]phenyl}piperazin-1-ylcarboxylate 
• 288250-15-7 N-[3-cyano-4-(piperazin-1-yl)phenyl]-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-37-3 1-(4-chlorophenyl)-N-[3-cyano-(4-piperazin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide 
• 288250-38-4 1-(4-chlorophenyl)-N-{3-cyano-4-[4-(3-hydroxypropyl)piperazin-1-yl]phenyl}-5-methylpyrazole-4-carboxamide 
• 288250-52-2 1-(4-chlorophenyl)-N-(3-cyano-4-{4-[3-(3-pyridyl)propyl]piperazin-1-yl}phenyl)-5-methylpyrazole-4-carboxamide 
• 288250-27-1 4-(4-{2-cyano-4-[1-(4-fluorophenyl)-5-methyl-4-pyrazolecarboxamide]phenyl}piperazin-1-yl)butyric acid 
• 288250-30-6 N-{3-cyano-4-[4-(5-methylisoxazol-4-ylcarbonyl)piperazin-1-yl]phenyl}-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-18-0 ethyl 4-(4-{2-cyano-4-[1-(4-fluorophenyl)-5-methyl-4-pyrazolecarboxamide]phenyl}piperazin-1-yl)butyrate 
• 288250-31-7 N-{3-cyano-4-[4-(2-cyano-3-hydroxycrotonoyl)piperazin-1-yl]phenyl}-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-26-0 4-(4-{2-cyano-4-[1-(4-fluorophenyl)-5-methyl-4-pyrazolecarboxamide]phenyl}piperazin-1-yl)butyric acid hydrochloride 
• 1085841-86-6 4-{2-cyano-4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR

The present invention is directed to piperidinyl and piperazinyl derivatives of formula (II) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and / or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.

DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS

Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES

The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.