288251-97-8

Upstream product

• 288251-99-0 3-cyano-4-(2-methylpropyl)benzoic acid 
• 134604-07-2 2-bromo-5-nitrobenzonitrile 
• 65238-58-6 3'-bromo-4'-isobutylacetophenone 
• 38861-78-8 1-(4-isobutyl-phenyl)-ethanone 
• 288251-98-9 3'-cyano-4'-isobutylacetophenone 
• 288251-96-7 2-(2-methylpropyl)-5-nitrobenzonitrile 

Downstream Products

• 288249-59-2 N-(3-cyano-4-isobutylphenyl)-1-(4-fluorophenyl)-3-methylpyrazole-4-carboxamide 
• 856167-67-4 5-bromo-2-(2-methylpropyl)benzonitrile 
• 856167-68-5 2-(2-methylpropyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 1334608-00-2 ethyl 4-(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)butanoate 
• 1334608-10-4 5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile 
• 1334608-14-8 5-(5-bromo-pyrimidin-2-yl)-2-isobutyl-benzonitrile 
• 1334608-18-2 5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile 
• 1334608-19-3 5-{5-[2-ethyl-3-(2-oxoethyl)phenyl]-2-pyrimidinyl}-2-(2-methylpropyl)benzonitrile 
• 1334608-23-9 ethyl 4-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)oxy]butanoate 
• 1334606-96-0 4-(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)butanoic acid 
• 1334608-27-3 methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate 
• 1334608-26-2 methyl N-[2-(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)ethyl]-N-methylglycinate 
• 1334607-77-0 4-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)oxy]butanoic acid 
• 1344998-91-9 C₃₀H₃₆N₄O₂S 

Relevant academic research and scientific papers

PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.

NOVEL S1P RECEPTOR MODULATING AGENT

An object of the present invention is to provide a compound having a modulating activity at an S1P receptor which is useful for preventing and treating autoimmune diseases, allergic diseases, and the like. According to the present invention, a compound re

PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Disclosed are pyrimidine derivatives for use as sphingosine 1- phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.

COMPOUNDS AS AGONISTS OF S1P1 RECEPTORS

Compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by S1P1 receptors.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.