856167-68-5

Usage

Molecular weight

369.24 g/mol

Appearance

Colorless to pale yellow liquid

Solubility

Insoluble in water, soluble in organic solvents

Chemical stability

Stable under normal temperature and pressure

Reactivity

Can react with strong acids, bases, and oxidizing agents

Usage

Stabilizer in polymer production, scavenger of free radicals in semiconductor manufacturing, potential use in OLEDs and semiconductor lithography, pre-registered under EU's REACH regulation.

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 873-62-1 m-cyanophenol 
• 189680-06-6 2-bromo-5-hydroxy-benzonitrile 
• 288251-96-7 2-(2-methylpropyl)-5-nitrobenzonitrile 
• 288251-97-8 5-amino-2-(2-methylpropyl)benzonitrile 
• 134604-07-2 2-bromo-5-nitrobenzonitrile 

Downstream Products

• 1334608-14-8 5-(5-bromo-pyrimidin-2-yl)-2-isobutyl-benzonitrile 
• 1334608-18-2 5-(5-{2-ethyl-3-[(E)-2-(methyloxy)ethenyl]phenyl}-2-pyrimidinyl)-2-(2-methylpropyl)benzonitrile 
• 1334608-19-3 5-{5-[2-ethyl-3-(2-oxoethyl)phenyl]-2-pyrimidinyl}-2-(2-methylpropyl)benzonitrile 
• 1334608-23-9 ethyl 4-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)oxy]butanoate 
• 1334608-27-3 methyl N-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)methyl]-N-methylglycinate 
• 1334608-26-2 methyl N-[2-(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)ethyl]-N-methylglycinate 
• 1334607-77-0 4-[(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)oxy]butanoic acid 
• 1334608-00-2 ethyl 4-(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)butanoate 
• 1334606-96-0 4-(3-{2-[3-cyano-4-(2-methylpropyl)phenyl]-5-pyrimidinyl}-2-ethylphenyl)butanoic acid 
• 1334608-10-4 5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile 
• 1373522-38-3 5-(3-(2-ethyl-3-(2-(piperidin-1-yl)ethyl)phenyl)-1,2,4-thiadiazol-5-yl)-2-isobutylbenzonitrile 
• 1373522-37-2 5-(3-(2-ethyl-3-(2-(3-hydroxyazetidin-1-yl)ethyl)phenyl)-1,2,4-thiadiazol-5-yl)-2-isobutylbenzonitrile 
• 1344996-22-0 1-(3-(5-(3-cyano-4-isobutylphenyl)-1,2,4-thiadiazol-3-yl)-2-ethylphenethyl)azetidine-3-carboxylic acid 
• 1344996-20-8 1-(3-(5-(3-cyano-4-isobutylphenyl)-1,2,4-thiadiazol-3-yl)-2-ethylphenethyl)piperidine-4-carboxylic acid 

Relevant academic research and scientific papers

From RORλt Agonist to Two Types of RORλt Inverse Agonists

Biaryl amides as new RORλt modulators were discovered. The crystal structure of biaryl amide agonist 6 in complex with RORλt ligand binding domain (LBD) was resolved, and both "short" and "long" inverse agonists were obtained by removing from 6 or adding

PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.

NOVEL S1P RECEPTOR MODULATING AGENT

An object of the present invention is to provide a compound having a modulating activity at an S1P receptor which is useful for preventing and treating autoimmune diseases, allergic diseases, and the like. According to the present invention, a compound re

PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS

Disclosed are pyrimidine derivatives for use as sphingosine 1- phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.

COMPOUNDS AS AGONISTS OF S1P1 RECEPTORS

Compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by S1P1 receptors.