288299-08-1

Upstream product

• 13837-60-0 2-ethynyl-2,6,6-trimethyl-3,4,5,6-tetrahydro-(2H)-pyran 
• 288299-06-9 2-[(E)-3-((R)-2,6,6-Trimethyl-tetrahydro-pyran-2-yl)-prop-2-en-(E)-ylidene]-succinic acid 1-ethyl ester 
• 288299-04-7 (E)-3-((R)-2,6,6-Trimethyl-tetrahydro-pyran-2-yl)-acrylic acid ethyl ester 
• 29171-20-8 3,7-dimethyloct-6-en-1-yn-3-ol 
• 13226-18-1 (R)-(-)-Cinenic acid 
• 13226-32-9 (R)-(-)-Cinenic acid methyl ester 
• 288299-07-0 3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester 

Downstream Products

• 24048-43-9 (R)-(+)-Curcumene ether 

Relevant academic research and scientific papers

Bisabolane sesquiterpenes: Synthesis of (R)-(+)-sydowic acid and (R)- (+)curcumene ether

A stereoselective synthesis of (R)-(+)-sydowic acid 1 and (R)-(-)- curcumene ether 2 is described. The enantiomerically pure tetrahydropyran building block (R)-(-)-cinenic acid 5 is obtained by resolution of the racemic acid. The aromatic moiety is constructed using a benzoannulation reaction as a key step. An easy way to the title compounds in racemic form is also reported.