288309-01-3Relevant academic research and scientific papers
Design, synthesis, and SAR of substituted acrylamides as factor Xa inhibitors.
Song, Yonghong,Clizbe, Lane,Bhakta, Chhaya,Teng, Willy,Li, Wenhao,Wu, Yanhong,Jia, Zhaozhong Jon,Zhang, Penglie,Wang, Lingyan,Doughan, Brandon,Su, Ting,Kanter, James,Woolfrey, John,Wong, Paul,Huang, Brian,Tran, Katherine,Sinha, Uma,Park, Gary,Reed, Andrea,Malinowski, John,Hollenbach, Stan,Scarborough, Robert M,Zhu, Bing-Yan
, p. 1511 - 1515 (2007/10/03)
Substituted acrylamides were used as templates that bridge P1 and P4 binding elements, resulting in a series of potent (sub-nanomolar) and selective factor Xa inhibitors. In this template, cis-geometry of P1 and P4 ligands is highly preferred. SAR on the substituting groups, as well as on modification of P1 and P4 moieties is described. Compounds in this series show good in vivo efficacy in animal models.
Inhibitors of factor Xa
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, (2008/06/13)
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
