288392-52-9Relevant academic research and scientific papers
A PROCESS FOR PRODUCING D-BIOTIN INTERMEDIATES
-
Page/Page column 8-9, (2021/11/13)
The present invention provides a process for producing a biotin intermediate compound of formula (I), or a geometrical isomer thereof or a geometrical isomeric mixture thereof in the presence of a catalyst, wherein R1 and R1' are independently H, lower alkyl, aryl or acyl group, optionally substituted by one or more substituents; and R2 is lower alkyl optionally substituted by lower alkoxyl or carboxyl group. According to the present invention, the process surprisingly reduces the reaction pressure while maintaining high yield and selectivity in industrial scale, and thus saves investment on facility and increases safety in industry.
