2884-26-6

Upstream product

• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 40886-58-6 (α-ethoxycarbonyl-α-4-methoxybenzoylmethylene)triphenylphosphorane 
• 100-07-2 4-methoxy-benzoyl chloride 
• 1073163-35-5 ethyl 2-diazo-3-(4-methoxyphenyl)-3-oxopropanoate 
• 51718-85-5 ethyl 3-(4-methoxyphenyl)propynoate 

Downstream Products

• 1082444-54-9 ethyl 4-(4-methoxyphenyl)-2-phenyl-1H-imidazole-5-carboxylate 
• 1082439-99-3 4-(4-methoxyphenyl)-2-phenyl-1H-imidazole-5-carboxamide 

Relevant academic research and scientific papers

Recyclable heterogeneous gold(I)-catalyzed oxidation of internal acylalkynes: Practical access to vicinal tricarbonyls

A highly efficient heterogeneous gold(I)-catalyzed oxidation of internal acylalkynes has been developed using 2,6-dichloropyridine N-oxide as the oxidant in dichloromethane (CH2Cl2) at room temperature, providing a novel and practical approach for the construction of diverse vicinal tricarbonyls such as α,β-diketoesters, 1,2,3-triketones, and α,β-diketoamides in good to excellent yields. The heterogeneous gold(I) catalyst can be readily obtained via a simple preparative procedure from commercially available reagents and recovered by filtration of the reaction mixture and reused up to seven times without significant loss of catalytic efficiency.

Water and fluorinated alcohol mediated/promoted tandem insertion/aerobic oxidation/bisindolylation under metal-free conditions: Easy access to bis(indolyl)methanes

A green tandem reaction, including insertion/aerobic oxidation/bisindolylation, starting from indoles and diazo compounds has been developed. The combination of water and fluorinated alcohol plays dual roles as solvent and promoter in this chemical transformation. Molecular oxygen in the air acts as an oxidant. 3,3′-Bis(indolyl)methanes with quaternary carbon were produced under metal-free conditions. No any catalyst and additive were required. N2 and water were released as sole by-products. Absence of water and fluorinated alcohol resulted in Wolff rearrangement product.

Synthesis and Photocatalytic Reactivity of Vinylsulfonium Ylides

Although sulfur ylides are textbook reagents in organic synthesis, surprisingly little variation of substituents on sulfur is usually observed. In particular, vinylsulfonium ylides have been neglected so far. Herein, we present a study on their synthesis and reactivity, including interesting behavior under photocatalytic conditions.

Metal-free α-hydroxylation of α-unsubstituted β-oxoesters and β-oxoamides

A direct metal-free α-hydroxylation of α-unsubstituted β-oxoesters and β-oxoamides was developed using m-chloroperbenzoic acid as the oxidant. This transformation enabled straightforward metal-free access to important α-hydroxy-β-dicarbonyl moieties under

OXAZOLE TYROSINE KINASE INHIBITORS

The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1 : provided that the sum of a and b is 0 or 1; T is O or NH Ar1 is a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S, and being optionally substituted by one or more substituents R1; Ar2 Js a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S and being optionally substituted by one or more substituents R2; and R1 and R2are as defined in the claims. The compounds are inhibitors of kinases and in particular FLT3, FLT4 and Aurora kinases.

5-6 or 5-7 Heterobicycles as Factor Xa inhibitors

The present application describes 5-6 or 5-7 heterobicyclics of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring P is a 5-membered heteroaromatic and ring M is a 6 or 7-membered non-aromatic carbocycle or heterocycle. Compounds o