1082444-54-9Relevant academic research and scientific papers
A multi-substituted imidazole derivatives method for the preparation of
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Paragraph 0033; 0034, (2017/04/11)
The invention provides a preparation method of multifunctional group-substituted imidazole derivatives including derivatives of 2,4,5-trisubstituted imidazole and 2-amino-4,5-disubstituted imidazole, and the derivatives are generated by alkenyl nitrine de
Synthesis of poly-functionalized imidazoles via vinyl azides annulation
Luo, Jing,Chen, Wenteng,Shao, Jiaan,Liu, Xingyu,Shu, Ke,Tang, Pai,Yu, Yongping
, p. 55808 - 55811 (2015/07/20)
An efficient annulation of vinyl azides with activated imines has been developed for the synthesis of poly-functionalized imidazole derivatives. This reaction includes thermal decomposition of vinyl azides to 2H-azirines, nucleophilic attack of 2H-azirines with activated imines and subsequent cyclization to desired imidazoles.
Carbene reactivity of 4-diazo-4H-imidazoles toward nucleophiles and aromatic compounds
Smith, Matthew R.,Blake, Alexander J.,Hayes, Christopher J.,Stevens, Malcolm F. G.,Moody, Christopher J.
experimental part, p. 9372 - 9380 (2010/03/04)
(Chemical Equation Presented) Carbenes derived from diazoimidazolecarboxylates 4 under thermal or photochemical conditions undergo O-H and N-H insertion reactions with alcohols and amines, respectively, in moderate yield, in competition with reduction in good H-donor solvents. Dichloromethane reacts to give the corresponding 4-chloroimidazole. Aromatic hydrocarbons are excellent traps for the imidazolylidene carbene and lead to a range of arylimidazole derivatives 7. Reaction with pyridine leads to the first example of a pyridinium ylide 8 formed from an imidazolylidene carbene, whereas irradiation in hexafluorobenzene gives the imidazoazocine 11, presumably by way of an initial norcaradiene intermediate.
OXAZOLE TYROSINE KINASE INHIBITORS
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, (2009/01/20)
The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1 : provided that the sum of a and b is 0 or 1; T is O or NH Ar1 is a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S, and being optionally substituted by one or more substituents R1; Ar2 Js a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S and being optionally substituted by one or more substituents R2; and R1 and R2are as defined in the claims. The compounds are inhibitors of kinases and in particular FLT3, FLT4 and Aurora kinases.
